Miscellaneous

Question 1

Characteristics of Lead poisoning (3)

Answer 1

Abdominal pain
Constipation
Neuropsychiatric features - Sensory peripheral neuropathy

Question 2

Investigations to Dx lead poisoning

Answer 2

Lead levels
Blood film - Basophillic stiplint (Blue spots on Red cells)

Question 3

Management of Lead poisoning

Answer 3

Chelatin agent - DMSA, EDTA, D-penecillamine

Question 4

Pathophysiology of lead poisoning

Answer 4

Defective ferrochelatase and ASA Dehydratase function

Question 5

Pathophysiology of methanol poisoning

Answer 5

Methanol is broken down by alcohol dehydrogenase to Formic acid and formaldehyde

These are the toxic metabolites

Question 6

Effects of formic acid

Answer 6

Blindness

Question 7

Rx of methanol poisoning

Answer 7

Fomepizole (Alcohol dehydrogenase competitive inhibitior

Question 8

What is the mechanism of action of fomepizole

Answer 8

Alcohol dehydrogenase inhibitor

Question 9

Fluid requirements for patients who need maintenance fluids over 24 hours

Answer 9

1mmol/Kg of Na+ and K+
30ml/kg of water
50-100g of glucose

Question 10

Risk of too much 0.9% Saline

Answer 10

hyperchloraemic Metabolic Acidosis