Misc

Question 1

Bosentan

Answer 1

endothelin-receptor antagonist that blocks the effects of endothelin (a potent vasoconstrictor that also stimulates endothelial proliferation).

• decreases pulmonary arterial pressure and lessens the progression of vascular and right ventricular hypertrophy.

Question 2

Etanercept

Answer 2

• inhibits tumor-necrosis factor (TNF) activity by competitively binding to TNF and preventing it from interacting with cell surface receptors.
• anti-inflammatory agent used for treatment of rheumatoid arthritis, psoriasis, and psoriatic arthritis.