Coagulation Drugs

Question 1

Direct thrombin inhibitors

Answer 1

dabigatran

associated with fetal toxicity in animal studies.

Question 2

factor Xa inhibitors

Answer 2

apixaban

have been associated with fetal toxicity in animal studies.

Question 3

Clopidogrel

Answer 3

blocks platelet adenosine diphosphate receptor and limits platelet aggregation, is used in treatment of coronary artery disease and acute coronary syndrome and prevention of recurrent ischemic strokes.

Question 4

Low-dose aspirin

Answer 4

prescribed to certain pregnant patients at risk of preeclampsia.

Question 5

Warfarin

Answer 5

• associated with fetal toxicity and should be avoided in pregnancy except in rare situations (eg, mechanical mitral valve).
• crosses the placenta, increasing risks of teratogenicity and fetal hemorrhage.