Adrenergic Blocking Drugs

Question 1

Esmolol

Answer 1

• selective β-1 adrenergic blocking agent with negative inotropic and chronotropic effects.
• cause a decrease in cardiac contractility.

Question 2

Clonidine

Answer 2

stimulates α2 adrenoceptors in the brainstem, resulting in reduced sympathetic outflow from the central nervous system,
- leading to a decrease in peripheral vascular resistance, heart rate, and blood pressure.

Question 3

α1-adrenergic antagonists (terazosin, doxazosin)

Answer 3

• commonly used for symptomatic benign prostate hyperplasia and are often associated with orthostatic hypotension, resulting in lightheadedness and syncope due to cerebral hypoperfusion upon standing.