Misc

Question 1

tx of chanchroid

Answer 1

ceftriaxone

Question 2

rubeola =

Answer 2

measles

Question 3

how does HPV cause cancer?

Answer 3

inactivation of p53 and Rb

Question 4

culture medium for bordetella pertussis

Answer 4

Bordet Gengou medium

Question 5

congenital deafness and PDA

Answer 5

congenital rubella

Question 6

what kind of murmur does rheumatic fever cause years later?

Answer 6

mitral stenosis (late diastolic murmur best heard at apex)

Question 7

MCC acute pericarditis

Answer 7

coxsackie b

Question 8

Nitro blue tetrazolium diagnostic test

Answer 8

detects presence of alk phos

absence means either CGD / dz of phagocyte function (NADPH oxidase defect)

Question 9

vanc “red man syndrome”

Answer 9

anaphylaxis from rapid infusion of vanc, caused by NON-IgE mediated release of histamine from mast cells / basophils

Question 10

umbilical cord fails to separate within the first few weeks of birth. what do you suspect?

Answer 10

LADS - defective integrins

Question 11

Bruton’s Agammaglobulinemia

Answer 11

defect in Bruton tyrosine kinase (BTK) - needed for maturation of b cells > no/low mature b cells > no plasma cells > low levels of all Ig > bacterial infxns

tissues normally containing b cells (ex tonsils, LNs, peyer’s patches) are small

XL

Question 12

cause of hyper IgM syndrome

Answer 12

defective CD40L

Question 13

Job syndrome

Answer 13

hyper IgE synd
dec neutrophil chemotaxis > recurrent staph infxns that are cold to the touch
due to failure of helper T cells to produce IFN gamma

FATED features:
facies (coarse)
abscesses (staph, cold)
teeth (primaries retained)
elevated igE
derm - eczema