MIDTERM: ACTIVITY 5 (ppt ni sir) Flashcards
PHYSICAL PROPERTIES
- Quality Assurance
- Stability Assessment
- Early Detection of Contamination
Detection of physical changes
Quality Assurance
Monitor and assess the stability of a drug over its shelf life
Stability Assessment
Reveal the presence of contaminants or impurities
Early Detection of Contamination
SOLUBILITY
principles
- Like Dissolves Like
- Solubility Product (Ksp)
- Formulation Development
- Drug Delivery Systems
- Bioavailability
Similar polarities are more likely to dissolve in one another
Like Dissolves Like
Constant value for a given solute-solvent system at a particular temperature.
Solubility Product (Ksp)
Selection of appropriate excipients and solvents for drug preparation.
Formulation Development
Achieving the desired drug release profiles
Drug Delivery Systems
Drug solubility and absorption
Bioavailability
MELTING POINT RANGE
- Eutectic Point
- Phase Transition
- Identification
- Purity Assessment
- Quality Control
the temperature from the point at which solid first begins to liquefy to the point at which the entire sample is liquid
melting point range
lowest temperature at which a substance changes from a solid to a liquid.
Eutectic Point
A change from solid to liquid occurs over a very narrow temperature range.
Phase Transition
Different compounds have distinct melting points.
Identification
