Microcirculation and Edema Flashcards
osmosis
movement of water across semipermeable membrane in response to concentration gradient
penetrating solute
go through cell membrane
ex: gas
nonpenetrating solute
charged
ex: anion, cation
Jvol equation
Kf (forces favor filtration [Pcap +pi Int])- (forces oppose filtration [Pint + pi cap])
pcap
inside capillary
hydrostatic pressure
Pint
outside capillary
hydrostatic pressure
Pi cap
oncotic pressure inside capillary
Albumin #1 contributer
Pi int
oncotic pressure outside capillary
vascular tone
how contracted smooth muscle is at any time
increase tone= increase constriction (resistance to bloodflow increases)
do capillaries has vascular tone
no, they do not contain smooth muscle!!
arterioles and veins do not effect constriction/ dilation
transcellular
goes from outside
needs help from transmembrane protein
paracellular
in between adjacent cells
force driving movement is chemical gradient
ascites
fluid
gas filled areas gone
urticaria
hives filled with serous fluid
non-cardiogenic pulmonary edema
fluid accumulates in the lungs, but not caused by the heart
factors that affect Pcap
increase/ decrease blood pressure
viscosity
(pa-pv)
loss of blood
factors that affect pi Int
toxins
blunt force trauma
lysis
continuous capillary
found in muscle, nerve, and adipose tissue
coated pits
fenestrated capillary
found in endocrine glands and glomerulus
fenestra covered with thin “diaphragm” like membrane
sinusoidal (discontinuous) capillary
found in sinusoids
large fenestrations/ gaps
most leaky
edema
interstitial and intracellular swelling
can be localized or widespread
capillary permeability is affected by
hypoxia, drugs, pathological conditions
