Micro lecture 6

Question 1

The two examples of cell envelope disruptors are: __________ & ________

Answer 1

Daptomycin & Colistin

Question 2

Daptomycin inserts itself into what type of bacteria cell membrane?

Answer 2

Gram-positive bacteria cell membrane.

Question 3

How does Daptomycin cause major disruption of cell function?

Answer 3

Daptomycin “Inserts” into Gram-POSITIVE cell membranes, aggregates,
causing leakage of ions from within leading to major disruption of cell
function.

Question 4

An agent that prevents the growth of bacteria is known as what?

Answer 4

A bactericidal.

Question 5

True or False? Daptomycin attaches to lipopolysaccharide and phospholipids in Gram-negative cell membranes, causing leakage of ions from within and major disruption of cell function.

Answer 5

False. Daptomycin “INSERTS” into Gram-POSITIVE cell membrane, aggregates,
causing leakage of ions from within and major disruption of cell
function.

Question 6

True or False? Daptomycin acts on Gram-positive bacteria membranes.

Answer 6

True. Daptomycin inserts into Gram-positive cell membranes.

Question 7

Colistin attaches onto what type of bacteria cell membrane?

Answer 7

Gram-negative bacteria cell membrane.

Question 8

How does Colistin cause major disruption of cell function?

Answer 8

Colistin attaches to lipopolysaccharide and phospholipids in Gram-negative cell membrane, causing leakage of ions from within
and major disruption of cell function.

Question 9

True or False? Colistin attaches to lipopolysaccharide and phospholipids in Gram-positive cell membranes, causing leakage of ions from within and major disruption of cell function.

Answer 9

False. Colistin acts on Gram-NEGATIVE bacteria cell membranes not Gram-positive.

However, the mechanism of action is correct.

Question 10

Daptomycin & Colistin are known as ____________ agents.

Answer 10

Bactericidal agents.