micro lecture 5

Question 1

list an example of a Glycopeptide

Answer 1

vancomycin (also teicoplanin)

Question 2

list facts about Glycopeptides

Answer 2

Origin - Streptomyces organisms

inhibit cell wall synthesis by forming a complex with the substrates that make up peptidoglycan (D-ala-D-ala)
(different to lactams)

Narrow-spectrum, restricted to G+ bacteria
(too big to penetrate the porins of G- cells)

“slowly/weakly” bactericidal

Question 3

_______inactivates MurA (inhibits peptidogylcan synthesis)

Answer 3

Fosfomycin

Question 4

____________enzymes are in existence on chromosome and transferrable plasmids

Answer 4

Fosfomycin resistance

Question 5

list 3 Fosfomycin resistance enzymes

Answer 5

FosA / FosB / FosX

Question 6

list facts about Fosfomycin

Answer 6

Origin - Streptomyces organisms

Usually for uncomplicated UTIs

Broad-spectrum against G+ and G-

“slowly/weakly” bactericidal

Question 7

list facts about Bacitracin

Answer 7

Origin – Bacillus subtilis organism

Interferes with peptidoglycan synthesis

Narrow-spectrum, usually for G+ organisms that cause skin infections

Question 8

explain the mechanism of action for Bacitracin

Answer 8

lecture five slide 7 (complete later)