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SPECIAL SENSE > [MICRO] DISEASES OF EYE > Flashcards

[MICRO] DISEASES OF EYE Flashcards

1
Q

normal biota of eye

A

staph. epidermidis
Lactobacillus
Propionibacterium

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2
Q

defense mechanisms of eye

A

eyelashes
eyelids
lacrimal & goblet cells secretions
lysozymes & IgA

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3
Q

infections of eyes are MC caused by

A

staph. aureus

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4
Q

infections of eyelids cause

A

blepharitis

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5
Q

infections of eyelid glands/follicles cause

A

sties

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6
Q

gram + cocci
beta hemolytic
catalase +
coagulase +

A

staph. aureus

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7
Q

causative agent of conjuctivitis
ferments mannitol
produces golden yellow endopigment
penicillin resistant

A

staph. aureus

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8
Q

virulence factors of staph. aureus (7)

A

1-protein A
2-clumping factor bound coagulase
3-antiphagocytic capsule
4-coagulase enzyme
5-beta lactamases
6-alpha toxin
7-P-V leukocidin

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9
Q

gram +
lancet shaped diplococci
alpha hemolytic
(-) by optochin
bile soluble

A

strept. pneumoniae

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10
Q

virulence factors of strept pneumoniae (2)

A

antiphagocytic capsule
IgA protease

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11
Q

conjunctivitis:
gram + lancet shaped diplococci producing alpha hemolytic colonies on blood agar

A

strept. pneumoniae

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12
Q

gram - rods
requires factor X & V for growth

A

H. infleunza

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13
Q

virulence factor of H. influenza (2)

A

antiphagocytic capsule
IgA protease

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14
Q

gram -
kidney bean diplococci
oxidase positive

A

N. gonorrhea

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15
Q

N. gonorrhea virulence factors (2)

A

Pili
IgA protease

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16
Q

non enveloped double stranded dna virus

A

adenovirus

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17
Q

causative agent of non specific follicular conjunctivitis

A

adenovirus

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18
Q

causative agent of acute pharyngoconjunctival fever

A

adenovirus serotype 3

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19
Q

unchlorinated swimming pools are associated w/ outbreaks of

A

adenovirus

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20
Q

non enveloped single stranded RNA viruses

A

Enterovirus 70
Coxsackie virus A24

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21
Q

outbreaks of severe hemorrhagic conjunctivitis are caused by

A

enterovirus 70
Coxsackie virus A24

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22
Q

enveloped double stranded DNA

A

Herpes simplex virus-1

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23
Q

virus which establishes latent infection in trigemnial ganglia in immunocompromised patients

A

herpes simplex virus-1

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24
Q

virus causing neonatal conjunctivitis accompanied by generalized herpes

A

herpes simplex virus-1

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25
Q

MOT of conjunctivitis

A

direct
indirect
autoinoculation

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26
Q

autoinoculation occurs in case of conjunctivitis caused by

A

N.gonorrhea
C.trachomatis

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27
Q

red eye
excessive lacrimation
purulent/watery discharge
are symptoms of

A

conjunctivitis

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28
Q

fever
pharyngitis
conjunctivitis
are symptoms of

A

acute pharyngoconjunctival fever (PCF)

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29
Q

causative agents of neonatal conjunctivitis

A

C.trochamatis
N.gonorrhea
Staph. aureus
Strept. pneumoniae

30
Q

most common causative agents of neonatal conjunctivitis

A

C.trochamitis
N.gonorrhea

31
Q

neonatal conjunctivitis is prevented by

A

erythromycin drops/ointment after delivery

32
Q

prevention of Chlamydial conjunctivitis

A

oral erthyromycin

33
Q

leading cause of non traumatic blindness

A

C.trochamitis

34
Q

non motile coccoid obligate IC bacteria

A

Chlamydiae

35
Q

cc of Chlamydiae

A

1-rigid wall
2-no peptidoglycan layer
3-group-specific, species-specific, immunotype-specific antigens
4-15 immunotypes (A-L)

36
Q

group specific lipopolysaccharide Ag are detected by

A

complement fixation tests

37
Q

species-specific & immunotype-specific Ag are detected by

A

immunofluorescence

38
Q

chlamydiae immunotypes causing trachoma

A

A,B, C

39
Q

chlamydiae immunotypes causing genital tract infections

A

D-K

40
Q

which chlamydiae immunotypes cause inclusion conjunctivitis

A

D-K

41
Q

chronic conjunctivitis endemic in africa & asia

A

trachoma

42
Q

MOT of trachoma

A

finger-to-eye
fomite-to-eye

43
Q

which cells does chlamydiae infect

A

epithelial cells of mucous membranes

44
Q

chlamydiae rarely causes___

A

invasive disseminated infections

45
Q

pathogenesis of trachoma

A

1-multiplies within conjunctival cells
2-kills cells
3-pus filled discharge
4-eyelids turn inwards
5-eyelashes scar cornea
6-scarring triggers invasion of BV
7-cornea no longer transparent

46
Q

metabolically inert form of C.trachoma

A

elementary body

47
Q

metabolically active form of C.trachoma

A

reticulate body

48
Q

replication cycle of C.trachoma

A

1-elementary body enters cell
2-elementary body reorganizes into reticulate body
3-cycles of binary fission
4-daughter reticulate bodies
5-reticulate bodies develop into elementary bodies
6-progeny elementary bodies released

49
Q

C.trachoma is stained & visualized through

A

inclusion bodies (site of replication within cells)

50
Q

mild conjunctival discharge
inflammation
pebbled appearance of upper eyelid
impaired vision

A

trachoma

51
Q

infants born to mothers w. trachoma develop

A

mucopurulent conjunctivitis

52
Q

cc of inclusion conjunctivitis

A

cornea isn’t affected
affects lower lid
recovery

53
Q

Reiter’s syndrome

A

autoimmune
antibodies against C.trachoma cross react with antigens on urethra, joints, uveal tract

54
Q

trachoma vaccine

A

NONE

55
Q

lab tests of trachoma

A

NAATs
PCR
enzyme immunoassay
fluorescein labeled monoclonal AB assay

56
Q

diagnostic smear of trachoma

A

conjunctivital smear

57
Q

trachoma TTT

A

infants—>tetracycline, erythromycin cream (10-14d)

adults—->oral tetracycline,doxycycline, erythromycin
(3-6w)

surgical correction of eyelid deformities

58
Q

aerobic gram - rods
non lactose fermenting on MacConkey
Pyocyanin pigment produced
oxidase positive

A

P.aeruginosa

59
Q

P.aeruginosa virulence factors (3)

A

exotoxin A
pili
antiphagocytic capsule

60
Q

exotoxin A of P.aeruginosa inactivates

A

elongation factor-2

61
Q

Protein A of staph.aureus binds to

A

Fc region of IgG to (-) opsonization
+ protects from phagocytosis

62
Q

HSV-1 reactivation in ophthalmic division of trigeminal ganglia causes

A

dendritic ulcer (corneal lesion)
severe keratoconjunctivitis

63
Q

recurrent keratitis may lead to

A

permanent corneal scarring & opacity

64
Q

epidemic keratoconjunctivitis is caused by

A

adenovirus serotypes 8 & 19

65
Q

gritty feeling in eye
sharp pain
conjunctivitis
sensitivity to light
opaque corneal lesions
small vesicles on conjunctiva
are symptoms of

A

keratoconjunctivitis

66
Q

keratoconjunctivitis TTT

A

topical+ oral acyclovir HSV
oral acyclovir herpes zoster ophthalmicus

67
Q

specimens used in diagnosis of eye infections

A

conjunctival swab
corneal scraping

68
Q

eye infections culture

A

blood & chocolate agar
5-10% CO2
gram stained films
PCR for viral infections

69
Q

infections of deep layers of eyes are caused by (5)

A

P.aeruginosa
Rubella
CMV
West nile fever
rift valley fever

70
Q

Rubella & CMV causes

A

cataract
microphthalmia
severe chorioretinitis in AIDS

SPECIAL SENSE (12 decks)

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