Methods in Drug Discovery Flashcards
What is drug discovery
a compound is found which is biologically active in the desired therapeutic area
what is drug development
a compound discovered to be biologically active then has that activity and its toxicology optimized for the clinic.
what is the pathway of drug development
observation of a beneficial effect
identification of component with positive attributes
identification of target
improved compound
formulation
development continues
What is the role of angiotensin II
is an octapeptide and is a potent vasoconstriction which increases blood pressure
What angiotensin II produced from
angiotensinogen and angiotensin converting enzyme (ACE)
What does inhibition of ACE do
prevent the raising of blood pressure
what is a me too drug
a drug containing an active pharmaceutical ingredient API which is chemically related and very structurally similar to an existing API.
