Heterolytic chemistry Flashcards
what is a heterocycle
a cyclic compound with one or moren on c atom in it
what do heterolytic drugs have good potential for
interacting with binding sites in enzymes
the main ones being hydrogen bond donors and hydrogen bond acceptors
what are heterolytic drugs useful for
lead compounds
probe structure activity relationship
when is a ring aromatic
it has 4n + 2 pi electrons
electrons are fully conjugated
it is planar
what does knowledge of the aromatic nature of these molecules allow us to predict
reactivities and devise appropriate synthesis of lead compounds and libraries of compounds
for pyridine what rule is followed
huckels ruleq
what is huckels rule
Hückel’s rule predicts that a planar ring molecule will have aromatic properties if it has 4n + 2 π electrons, where n is a non-negative integer
is pyridine nucleophilic
yes due to the ability of it to react with other binding site due to its electrons
what is the difference between benzene and pyridine
slight change from perfect hexagonal geometry due to the presence of heteroatom (shorter cn bond)
the replacement of hydrogen in the plane of the ring with an unshared electron pair not involved with the pi electron aromatic sextet
a strong permanent dipole dipole owing to greater electronegativity of N
is pyradine basic or acidic
basic
is pyridine a nucleophile or an electrophile
nucleophile
what cannot be made using reactions of pyridine with electrophiles
pyridine compounds with subsituents on the carbon atoms
at what positions do pyridine react readily with nucelophiles
2 and 4
in reactions with pyridine and nucleophiles what happens regarding aromaticity
restored at the end of the reaction
