Metabolismo colesterol Flashcards

1
Q

El colesterol es precursor de:

A
  • Hormonas esteroideas
  • Ácidos biliares
  • Vitamina D
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2
Q

Precursor de la síntesis del colesterol

A

Acetil CoA

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3
Q

Sitio celular donde ocurre

A
  • Citosol
  • Membrana del REL
    De tracto digestivo e Hígado
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4
Q

Acetil CoA + Acetil CoA –> Acetoacetil-CoA

A

Enzima: Tiolasa ó Acetil-CoA aciltransferasa

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5
Q

Acetoacetil-CoA –> HMG-CoA + CoA

A

Enzima: HMG-CoA sintasa
Utiliza CoA y 2NADPH

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6
Q

Rate limiting step

A

HMG-CoA –> Mevalonato
Enzima: HMG-CoA reductasa

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7
Q

Inhibe a la HMG-CoA reductasa

A
  • Ácidos biliares
  • Mevalonato
  • Estatinas
  • Colesterol
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8
Q

¿Qué se hace para obtener isopentenil di fosfato?

A

Se fosforila y descarboxila el mevalonato
Utiliza ATP

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9
Q

¿Cuántas unidades de isopentenil forman escualeno?

A

6

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10
Q

Farnesil pirofosfato –> Escualeno

A

Enzima: Escualeno sintasa

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11
Q

Escualeno –> Lanoesterol

A

Enzima: Oxidoescualeno ciclasa

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12
Q

¿Quién es el esteroide madre?

A

Lanosterol

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