Beta Oxidación Flashcards

1
Q

Proceso:

A

Convertir un ácido graso a acetil CoA

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2
Q

Sitio celular donde ocurre

A

16 -18 C = matriz mitocondrial
+ 18 C = peroxisomas

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3
Q

Cuando oxidamos cadenas de ácidos grasos de cadena par obtenemos:

A

Acetil CoA

  • Se va a KREBS y produce ATP
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4
Q

Cuando oxidamos ácidos grasos de cadena impar obtenemos:

A

Propionil CoA

  • Produce succinil, se va a KREBS, se produce OAA y empieza gluconeogénesis
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5
Q

La hormona sensitiva lipasa es activada por:

A

Glucagón

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6
Q

Acción de la hormona sensitiva lipasa:

A

Corta triglicéridos =
Glicerol + 3 Ácidos Grasos

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7
Q

Los ácidos grasos entran al torrente sanguíneo y viajan en forma de ____________ hacia su célula diana y entra al citosol

A

Albúmina

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8
Q

Ácido graso –> Acil CoA

A

Enzima: Acil CoA sintetasa
Utiliza CoA, 2 ATP

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9
Q

¿Qué necesita el acil CoA para entrar a la mitocondria?

A

Carnitina
Enzima: Carnitina acil transferasa I (membrana externa)
- Sale CoA
- Acilcranitina entra a la membrana interna

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10
Q

Inhibe a la Carnitina acil transferasa I

A

Malonil CoA
*Viene de Síntesis de ácidos grasos

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11
Q

Enzima que le quita la carnitina al acil y le agrega CoA

A

Carnitina acil transferasa II
Produce = Acil CoA

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12
Q

1er paso de la beta-oxidación:
Acil CoA –> Enoil Coa

A

Enzima: Acil CoA DH
Utiliza FAD+ sale FADH2

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13
Q

Enoil CoA –>Beta-Hidroxi acil CoA

A

Enzima: Enoil CoA hidratasa

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14
Q

Beta-Hidroxiacil CoA –> Beta-cetoacil CoA

A

Enzima: Beta-Hidroxiacil CoA DH
Utiliza NAD+ sale NADH

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15
Q

¿Cuántas vueltas se le da al ciclo?

A

7

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15
Q

Beta-cetoacil –> Acetil CoA + Acil CoA

A

Enzima: Beta-cetotiolasa

16
Q

Con 7 vueltas de Beta-oxidación, ¿Cuántos Acetil CoA se producen?

A

8 Acetil CoA

Por lo tanto…
Si entran a KREBS producen 80 ATP + FADH + NADH (28 ATP) = 108 - 2 () = 106 ATP

17
Q
A