Metabolic Bone Manifestations of GI Diseases

Question 1

Give conditions of GI diseases that has Metabolic bone manifestations

Answer 1

1. Chron’s Disease
2. Ulcerative Colitis
   = Osteomalacia/Osteoporosis
3. Celiac Sprue= rickets/osteomalacia
4. Post Gatrectomy= Osteoporosis
5. Primary Biliary Cirrhosis- Osteomalacia/osteoporosis

Question 2

Mechanisms:

Answer 2

1. Calcium malabsorption alone or combined with malabsorption of Vit D
2. Impaired absorption of Vit D, altered metabolism of Vit D, reduced enterohepatic circulation of Vit D
3. Glucocorticoid treatment of IBD