Hematologic Disorders with Associated Arthropathies

Question 1

It is marked by flawed hemoglobin

Answer 1

Sickle Cell Disease

Question 2

The osteoarticular involvement in sickle cell disease has been poorly studied and it is mainly characterized by:

Answer 2

1. Osteonecrosis
2. Osteomyelitis
3. Arthritis

Question 3

The deoxygenation and polymerization of _______________, which results in sickling and vascular occlusion, occur more often in tissues with low blood flow, such as in the bones. Bone microcirculation is a common place for erythrocyte sickling, which leads to thrombosis, infarct and necrosis.

Answer 3

hemoglobin S

Question 4

Pathogenesis of sickle cell disease

Answer 4

1, Microvascular Occlusion

Question 5

A frequent complication in sickle cell disease, with a painful and debilitating pattern.
generally insidious and progressive, affecting mainly the hips (femur head) and shoulders (humeral head).

Answer 5

Osteonecrosis

Question 6

Also known as hand-foot syndrome, is an acute vaso-occlusive complication characterized by pain and edema in both hands and feet, frequently with increased local temperature and erythema.

Answer 6

Dactylitis

Question 7

The most common form of joint infection in sickle cell disease.

Answer 7

Osteomyelitis

Question 8

A condition usually an inherited bleeding disorder in which the blood does not clot properly.

Answer 8

Hemophilia

Question 9

1. The main cause of chronic pain and disability in people with severe hemophilia.
2. Answer on no. 2 most commonly occurs in?

Answer 9

1. Joint Bleeds
2. Knees, Elbows, and Ankles

Question 10

Pathogenesis of Hemophilia

Answer 10

1. multifactorial, with changes occurring in the synovium, bone, cartilage, and blood vessels

Question 11

Hemophilia A

Answer 11

Factor 8

Question 12

Hemophilia B

Answer 12

Factor 9