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Rheum Ortho > Metabolic Bone Disease > Flashcards

Metabolic Bone Disease Flashcards

1
Q

What is Osteoporosis?

A

Bone Deterioration w/ Reduced bone mass.
Disruption of micro architecture of bone
Inc risk of fracture

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2
Q

What is Osteoporosis?

A

Bone Deterioration w/ Reduced bone mass.
Disruption of micro architecture of bone
Inc risk of fracture

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3
Q

What does the T-Score of Bone density tell you?

A

Comparison to young Adults

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4
Q

What does the Z-Score of Bone density tell you?

A

Comparison to Age matched adults

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5
Q

What T score is equated to osteoporosis?

A

T score

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6
Q

What T score is equated to Low bone density (osteopenia)?

A

-1.0 to -2.5

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7
Q

What is a normal T score?

A

-1.0 to +1.0

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8
Q

Who should T-Score NOT be used for?

A

Children
Pre-Menopausal Women
Men

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9
Q

When is a Z score used?

A

Pt younger than peak bone mass
Pre-Menopausal Women
BD Lower than expected
Men

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10
Q

What are clinical Risk factors for fragility fracture?

A 
Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP
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11
Q

What are clinical Risk factors for fragility fracture?

A 
Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP
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12
Q

What is the Reccomended Daily Ca intake?

A

800 to 1000 IU/d of Vit D3

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13
Q

What does the Z-Score of Bone density tell you?

A

Comparison to Age matched adults

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14
Q

What T score is equated to osteoporosis?

A

T score

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15
Q

What T score is equated to Low bone density (osteopenia)?

A

-1.0 to -2.5

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16
Q

What is the MOA of DENOSUMAB?

A

Binds RANK ligand and Inh Osteoclast Med-Bone Destruction

17
Q

Who should T-Score NOT be used for?

A

Children
Pre-Menopausal Women
Men

18
Q

When is a Z score used?

A

Pt younger than peak bone mass
Pre-Menopausal Women
BD Lower than expected
Men

19
Q

What Z-Score equates to 2^ osteoporosis?

A

less than -2.0

20
Q

What are clinical Risk factors for fragility fracture?

A 
Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP
21
Q

What kind of rickets is caused by Dietary Def of Vit D and/or Ca?

A

Calcipenic Rickets

22
Q

What is the Reccomended Daily Ca intake?

A

800 to 1000 IU/d of Vit D3

23
Q

What testing is recommended for women >65 and Men >70?

A

BMD testing

24
Q

What are the limitations of FRAX?

A

only applied to Pts naive to Tx

Only T-Score from the hip. not peripheral or Spine T-Score

25
Q

What is the Tx of Osteoporosis?

A

Anticat Bisphosphonates/ SERM/Denosumab) vs Anabolic Thx

26
Q

What is the MOA of DENOSUMAB?

A

Binds RANK ligand and Inh Osteoclast Med-Bone Destruction

27
Q

What are the traits of Paget’s Disease of the bone?

A

Abn of the osteoclast. accel bone turnover and abn bone remodeling. AD w/ var penitrance

28
Q

What are clinical signs of PDB?

A

Radic due to Nerve Compression, Back pain, Hearing loss, headache, Joint rep surgery, High OP HF. Hyper Calcuria

29
Q

What are lab findings in PDB?

A

Inc bone turnover => Inc Alk phos, Bone TO markers increased => Ca and Phos normal

30
Q

What is the Treatment of PDB?

A

Monitor Alk phos

Bisphosphonates - Zoledronic Acid

31
Q

What kind of rickets is caused by Dietary Def of Vit D and/or Ca?

A

Calcipenic Rickets

32
Q

What kind of rickets is caused by Renal Phosphate Wasting?

A

Phosphopenic Rickets

33
Q

What are the lab findings in Osteomalacia?

A 
Alk phos Elevated
Serum Ca and Phos reduced
Urine Ca low in 87% 
Low 25 OH VD
PTH elevated

Rheum Ortho (11 decks)

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