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rheum ortho > Bone Path II > Flashcards

Bone Path II Flashcards

1
Q

What are the Clinical Features of Hyperparathyroidism?

A

Bones, Stones, Groans(GI), Moans(CNS)

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2
Q

What is the effect of PTH?

A

Inc Resorption of Ca by renal Tubules

Inc synth of active VD by kidneys => Inc Ca abs from gut

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3
Q

What is the Phys Effect of Hyper PTH?

A

Inc SERUM Ca and Phosphate

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4
Q

WHat are the bone changes occurring from HPTH?

A

Causes Bone Cysts and Brown Tumors

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5
Q

WHat are the effects of Renal filure in Renal osteodystrophy?

A

Renal Failure => D3 Deficiency => HypoCa => 2^HPTH

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6
Q

WHat are the effects ofHPTH in Renal osteodystrophy?

A

Inc PTH => Inc Osteoclasts => Inc Serum Ca and Phos => Bone cysts and Brown tumors

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7
Q

What are the traits of Paget’s disease of bone?

A

Simultaneous:

1) Osteoclast mediated bone resorption
2) Imperfect osteoblast-med bone repair Early(1) Late (2)

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8
Q

What type of virus is thought to contribute to Paget’s disease of bone?

A

Paramyxovirus

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9
Q

What is the Mnemonic for Different Collagen types?

A

bONE
carTWOlage
reTHREEculate(reticulate)
FOUR is floor (Basement Membrane)

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10
Q

What is Avascular Necrosis?

A

Infarct of bone and marrow

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11
Q

What are the causes of Avascualr necrosis?

A

Fracture, Corticosteroids, Idiopathic**

Thrombus and Embolism, vasculitis, radiation, inc intraosseus pressure

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12
Q

What are the steps of Fracture Healing?

A

Bleeding =>Organization of Hematoma (procallus) => fibrocartillaginus callus => Mesenchymal cells replaced by osseus callus

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13
Q

What are the inhibitors of Fracture healing?

A

Infection, Non-union, Inadequate immobilization, poor circulation/nutrition, drugs(imm-supp), systemic abnormality

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14
Q

What are the routes of Osteomyelitis?

A

Hematogenous, Extension from adjacent acute inflammation, from open fracture or surgery

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15
Q

What is the most common microbe causing osteomyelitis?

A

Staph Aureus. Salmonella in sickle cell patients (asplenic?)

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16
Q

What are the traits of Chroic Osteomyelitis?

A

“Sequestrum”

17
Q

“Sequestrum”

A

infection surrounded by rim of reactive bone. Involucrum

18
Q

What are the outcomes/ complications of Chronic Osteomyelitis?

A

Heal, Drain into sinus tract, walled off => Brodie abcess

Pathologic fracture, endocarditis, sepsis, Sq Cell CA

19
Q

Brodie abcess

A

Well defined rim of sclerotic bone surrounds residual abcess

20
Q

What are the traits of Tuberculous Osteomyelitis?

A

Hematogenous spread, long bones and VERTABRAE. Pott Disease

21
Q

What are the Effects of Pott Disease?

A

Vertebral deformity and Collapse => Neurologic Deficits

rheum ortho (11 decks)

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