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Rheum Ortho > Bone Pathology > Flashcards

Bone Pathology Flashcards

1
Q

What is Uncalcified bone called?

A

Osteoid

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2
Q

What receptors are found on Osteoblasts?

A

RANK-L

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3
Q

What are osteoclasts derived from?

A

Hematopoetic Progenitor Cells

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4
Q

What pervents parts of bone from being resorbed?

A

Lined w/ osteoid

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5
Q

What is the difference between Woven and Lamellar bone?

A

Woven: Random weave
Lamellar: Organized. Stronger

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6
Q

Where is Woven bone seen?

A

Fetal skeleton and growth plates, Callus, Fibrous Dysplasia, Surrounding tumor or infection

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7
Q

What are the traits of Achondroplasia?

A

Dwarfism. Def in signal transduction. FGFR Persistently activated. Dec prolif of chondrocytes @ growth plates. AD. HH Lethal
Hh Dwarfed

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8
Q

What are the zones of The Growth Plate?

A

1) Reserve Z
2) Proliferation Z
3) Hypertrophy
4) Mineralization
5) Primary Spongiosa

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9
Q

What are the Clinical findings of achondroplasia?

A

Shortened proximal extremities
Sway Backed posture
Enlarged head w/ fontanel

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10
Q

What is the defect in Osteogenesis Imperfecta?

A

Type 1 collagen synthesis

AD. Brittle Bones

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11
Q

What are the 4 major types of OI?

A

1) inc risk of fracture but not deforming
2) Lethal: In utero demise
3/4) Survive fracures in infancy/childhood but have progressive Deformity

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12
Q

What are the features of OI type 1?

A

Blue Sclerae, Dental and hearing problems, Inc risk lof fracture

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13
Q

What are the traits of Osteopetrosis?

A

Marble bone disease
Dec in Osteoclastic bone resorption => skeletal sclerosis. Inc mineralization
Thick brittle bones

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14
Q

What are the hematologic signs of Osteopetrosis?

A

Anemia, thrombocytopenia, Inc risk of infection

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15
Q

What are the traits of Osteoporosis?

A

Reduced bone mass

Cortex and Trabeculae are thinned

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16
Q

How do Osteoblast and clasts interact?

A

RANK ligand on surface of OClast precursor stim by OBlast => diff to mature OClast

17
Q

What is the Effect of Dec Estrogen on Osteoclasts?

A

Inc IL-1, IL-6, TNF => Inc RANK => Inc Osteoclasts => Bone resporption => Dec Osteoprotegrin

18
Q

What are the 2 types of Vertebral Fractures?

A

Wedge Fracture => Kyphosis

Burst Fracture => SC disruption

19
Q

What are the effects of Glucocorticoids on the Bones?

A

Dec Osteoclastogenesis
Dec Osteoblastogenesis =>
Osteonecrosis and Fracture

20
Q

What are the traits of Rickets and osteomalacia?

A

VD Deficiency => Defective Matrix Mineralization

Softening of Bone => Frac/ deformity

21
Q

What are the Clinical signs of Osteomalacia?

A

…

22
Q

What are the Clinical signs of Rickets?

A

Imp growth, Pigeon Chest, notched ribs, Dental Defects, Rachitic Rosary, Enl abdomen, chronic cough,(Ribs don’t grow)

Rheum Ortho (11 decks)

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