Mental Illness Flashcards
Who is Freud?
One of the first big names in psychotherapy.
Schizophrenia (symptoms (7) and treatment)
Symptoms: hallucinations, confused thinking, magical thinking, false beliefs, anxiety disorders, feelings of persecuation, and lack of emotion.
Antihistamines were used to treat these patients - thorazine specifically. It gave rise to lip smacking, grimacing, dikensia - Parkinson’s disease symptoms. It was a dopamine antagonist.
Where did they get the ideas for mental health drugs?
Before, using dopamine receptors, D2 specifically.
After, using animal studies, lookng for patterns.
Typical antipsychosis.
Had worse side effects (Parkinson’s)
Ended in zine, xol, xene, dol, zide, and loxapine
Atypical antipsychosis.
Weak D2 antagonists, strong serotonin agonists, better side effects.
Ended in pine, zole, done.
Tricyclic antidepressants.
Imipranine. Blocked serontonin reuptake, increasing serotonin level. Is a dopamine antagonist. Histamine antagonist, acetylcholine antagonist.
Ipronazid drug for mental health.
It’s an antidepressant. Inhibits the enzyme MAO. It increases serotonine by reducing the degredation of it.
Prozac for mental health.
Can treat anxiety and depression disorders. It has a clean side effect profile. It is a selective serotonin reuptake inhibitor.
Drugs to treat OCD.
Prozac (SSRI) and MAO inhibitors.
Lithium for mental health.
Found to calm manic patients. Has a narrow therapeutic window. Only 1 atom, so can’t design new drug from it.
Barbituates and Benzodiazapines for mental health.
Barbituates: Treats depression, anxiety. GABA agonists. They reduce neural activity but have a lot of side effects.
Benzodiazapines: stronger barbituates, amplier GABA signaling.
Why is it difficult to come up with more effective mental illness drugs?
Animal brains are too simple, human experiments are difficult, the theories are based off of drug effects.
