Mental Health Flashcards
How prevelant is depression in primary care?
Discuss some important aspects of history to explore in patient presenting with suspected depression
- Assess suicide risk
- Consider any factors which may affect development, course or severity of depression e.g. history of depression, living coniditons, employment etc….
- Identify any safeguarding issues
- Assess for any comorbid conditions associated with depression
- Use a validated tool to assess depression
Discuss some risk factors for depression
- Personal or family history of depressive disorder
- Co-existing medical conditions
- Age >65yrs
- Oral contraceptives
- Corticosteroids
- Recent childbirth
- Adverse childhood experiences
*
Discuss typical presentation of depression; hightlight two/three core symptoms
*NOTEL these are symptoms used in DSM-5 criteria
Core Symptoms
- Feeling down, depressed or hopeless
- Little interest or pleasure in doing things
- Reduced energy (only core symptom on ICD10)
Associated Symptoms
- Disturbed sleep (decreased or increased compared to usual).
- Decreased or increased appetite and/or weight.
- Fatigue/loss of energy.
- Agitation or slowing of movements.
- Poor concentration or indecisiveness.
- Feelings of worthlessness or excessive or inappropriate guilt.
- Suicidal thoughts or acts.
What criteria do we use to diagnose depression? Describe this criteria
DSM-5 criteria:
- Have at least one of the two core symptoms of depression (feeling low & lack of interest) for most days for over 2 weeks
- Explore to see if have any other symptoms of depression to help classify severity into:
- Subthreshold depression
- Mild depression
- Moderate depression
- Severe depression
For each of the following categories of depression, discuss DSM-5 criteria for each:
- Subthreshold depression
- Mild depression
- Moderate depression
- Severe depression
FOR ALL, must have at least one of two core symptoms aswell as:
- Subthreshold depression: total of 2-4 symptoms
- Mild depression: few, if any, symptoms in excess of five symptoms and they only result in minor functional impairment.
- Moderate depression: is diagnosed if symptoms or functional impairment are between mild and severe.
- Severe depression: has most symptoms and they markedly interfere with functioning – they can occur with or without psychotic symptoms.
What is dysthmia?
Peristent subthreshold depression: subthreshold symptoms for more days than not for at least 2 years, which is not the consequence of a partially resolved ‘major’ depression.
What is seasonal affective disorder?
Episodes of depression which recur annually at the same time each year with remission in between (usually appearing in winter and remitting in spring).
Discuss what investigations you might do, if any, for someone presenting with suspected depression
Largely a clinical diagnosis however may consider investigations to rule out other pathology e.g.:
- FBC: rule out anaemia as cause for fatigue
- TFTs: rule out thyroid pathology
- Glucose: rule out diabetes as cause for fatigue
- U&Es:
- LFTs:
- Calcium:
May do a ‘metabolic panel’ tests for most of aboive
What is PHQ-9 questionnaire?
Depression questionnaire that reflects the DSM-5 criteria. It classifies current symptoms on a scale of 0 (no symptoms) to 4 (daily symptoms). It has been validated for use in primary care settings. Repeating the PHQ-9 during treatment allows the clinician to objectively monitor response to therapy.
State some of the questions on the PHQ 9 questionnaire
Remember, patient answers each question on scale of 0 (no symptoms) to 4 (daily symptoms) and a total score is produced. Over the last 2 weeks how often have you been bothered by any of the following:
- Little interest/pleasure in doing things
- Feeling down, hopeless, depressed
- Trouble falling alseep or staying asleep
- Feeling tired or having little energy
- Poor appetite or overeating
- Feeling bad about yourself- like you are a failure or have let your family or yourself down
- Trouble concentrating on things
- Moving or speaking so slowly that other people have noticed (or the opposite- being figety and unable to keep still)
- Thoughts of hurting yourself or that you would be better off dead
*NOTE: 10th question not included in score that asks how difficult these symptoms/feelings have made everyday life e.g. work, take care of things at home, get along with other people etc..
Interpret the following scores on PHQ 9:
- 0-4
- 5-9
- 10-14
- 15-19
- 20-27
- 0-4: minimal depression
- 5-9: mild depression
- 10-14: moderate depression
- 15-19: moderately severe
- 20-27: severe depression
State some other depression screening tools (other than PHA-9)
- Edinburgh Potnatal Depression Scale
- HADS-10
- BDI-II
Discuss how you would manage someone with subthreshold depression or someone with mild depression who does not want intervention
- Dicuss problems & concerns
- Provide information about nature & course of depression
-
Offer advice to help boost mood:
- Talking to family & friends
- Enough sleep
- Nutrition
- Relaxation techniques
- Arrange follow up in 2 weeks (contact if they don’t turn up)
Discuss the management of someone with persistent subthreshold depressive symptoms or mild to moderate depression
- Consider low intensity psychosocial intervention
- Offer group CBT if decline low intensity psychosocial intervention
-
Consider antidepressants if:
- History of moderate or severe depression
- Subthreshold depressive symptoms >2yrs
- Other interventions not worked
- Depression is complicating care of a chronic physical health problem
Discuss the management of moderate or severe depression
- Antidepressant
- High intensity psychological intervention
- Counselling if decline both of above
- Offer sleep hygience advice for those who have difficulty sleeping
- Provide information & advice about depression & it’s treatment
The Mental Health Act allows compulsory admision of people who…. (2)
- Have a mental disorder of a nature or degree that warrants assessment or treatment in hospital
- Needs to be admitted in the interests of their own health or safety, or for protectin of other people
Discuss the difference betwen low and high intensity pyshcological interventions
- Low intensity: individual does a lot of work themselves with less support from professionals e.g. individual guided self-help based on principles of CBT (e.g. via workbooks, websites etc..) with a few short face to face or telphone consultaitons
- High intensity: professionals more heavily involved, mainly based around sessions and healthcare professional and pt doing work together e.g. indiviudal CBT, couples therpay etc…
*NOTE: may see group CBT as an inbetween
Alongside management already discussed for different categories of depression, what should you offer all pts with depression?
- Verbal & written information
- Advice about self-help groups
- Advice about organisations e.g. MIND, Samaritans
What should you explain to someone who is starting antidepressants?
- Explain suicide risk (increased risk of suicide when first start taking)
- Symptoms of anxiety may initially worsen
- Take time to work
- Need to continue for at least 6 months after symptoms have resolved to reduce risk of relapse
- Do not suddenly stop taking them
- Antidepressant drugs are not addictive but 1/3 peole experience discontinuation symptoms
- Some antidepressants have sedating effects and may affect a person’s ability to drive; effect likely to be greates in first month. Don’t drive if affected
What antidepressants should be prescribed in patients with depression?
*Include first line, second line etc…
- First line= SSRI (NOTE: if pt has had good response to antidepressant previously can go with sam one)
- Second line= increase dose or switch to different SSRI or try TCA
- Third line= consider other antidepressants e.g. Mertazepine
Describe the mechanism of action of the following drugs:
- SSRIs
- SNRIs
- TCAs
- SSRIs: inhibit reuptake of serotonin to increase serotonin in synaptic cleft and therefore increase binding to post-synaptic receptor
- SNRIs: inhibit reuptake of noradrenaline to increase noradrenaline in synaptic cleft and therefore increase binding to post-synaptic receptor
- TCAs: block reuptake of serotonin and noradrenaline to increase concentrations in synaptic cleft and increase bindng to post-synaptic receptor
Which SSRI is preferred in patients with chronic physical health problems?
Sertraline as it has lower risk of drug interactions
State some examples of:
- SSRIs
- SNRIs
- TCAs
- SSRIs: citalopram, fluoxetine, paroxetine, sertraline
- SNRIs: desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
- TCAs: amytriptyline, nortriptyline, doxepine
For each of the following conditions/situations, state which antidepressants should not be offered:
- NSAIDs
- Warfarin
- Heparin
- Aspirin
- Anti-epileptic drugs
- Triptans
- MAO-B
- Flecainide
- NSAIDs: avoid SSRIs and SNRIs (but if not suitable alternative found offer GI protection)
- Warfarin: avoid SSRIs, SNRIs, TCAs
- Heparin: SSRI and SNRIs
- Aspirin: SSRIs and SNRIs
- Anti-epileptic: seek specialist advice as all antidepressants lower seizure threshold
- Triptans: SSRIs
- MAO-B: SSRIs
- Flecanaide: do not offer citalopram or escitalopram
State some ADRs of SNRIs and SSRIs
- feeling agitated, shaky or anxious
- feeling and being sick
- indigestion and stomach aches
- diarrhoea or constipation
- loss of appetite
- dizziness
- not sleeping well (insomnia), or feeling very sleepy
- headaches
- low sex drive
- difficulties achieving orgasm during sex or masturbation
- in men, difficulties obtaining or maintaining an erection (erectile dysfunction)
These side effects should improve within a few weeks, although some can occasionally persist.
State some ADRs of TCAs
- dry mouth
- slight blurring of vision
- constipation
- problems passing urine
- drowsiness
- dizziness
- weight gain
- excessive sweating (especially at night)
- heart rhythm problems, such as noticeable palpitations or a fast heartbeat (tachycardia)
The side effects should ease after a couple of weeks as your body begins to get used to the medicine.
What is serotonin syndrome?
- Adverse drug reaction caused by excessive central and peripheral serotonin
- Can occur hours-days after initiation of new drug, dose escalation or overdose
- Symptoms vary from mild to life-threatening & can be classifed into three main categories:
- Neuromuscular hyperactivity (tremor, hypereflexia, rigidity)
- Autonomic dysfunction (tachycardia, hyperthermia, diaphoresis, nausea & vomiting)
- Altered mental state (agitation, confusion, mania)
Can someone take St John’s wort with depression tablets?
NO
What monitoring needs to be done for patients on antidepressants?
Depends on drug and pt but consider:
- U&E’s to monitor sodium
- BP
- ECGs
- Mood
Which patients are at increased risk of devlopoing hypontraemia whilst taking SSRIs?
- Older age
- History of hyponatraemia or low baseline sodium
- Co-therapy with drugs known to cause hypokalaemia
- Low body weight
- Medical comorbidity
What follow up is required for someone who has been diagnosed with depression?
- Arrange initial follow up 2 weeks later **NOTE: if suicidal or <30yrs this should be done in 1 week
- Review regularly (e.g. every 2-4 weeks) next 3 months
- If response is good consider longer intervals