Mental Health Flashcards

1
Q

what does the brain control?

A

behavior - but not all behavior can be easily controlled

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2
Q

what was mental illness thought to be caused by? what was a common treatment?

A

demons, trepanation

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3
Q

it is believed you can fix a person’s behavior how?

A

torture - asylums, prisons

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4
Q

who started psychotherapy?

A

Freud

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5
Q

What is a lobotomy?

A

needle through the eye socket and wiggle it to separate one part of the brain from another part that controls behaviour - main benefit were to the people around them

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6
Q

electroshock, is it used today?

A

zapping someone which high voltage electricity - in 50’s this was horrible and painful
we still do this they just put you under anesthesia

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7
Q

What did asylums turn into in the 50’s?

A

mental hospitals - more medical treatment

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8
Q

Treatment for schizophrenia (hallucinations + anxiety)

A
  1. antihistamines - calmed surgical patients

Thorazine- first effective treatment (25% achieved remission)
- dopamine antagonist- reduces psychosis

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9
Q

Side effects of Thorazine:

A

similar to Parkinson’s disease - involuntary facial expressions

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10
Q

What are the effects of amphetamines?

A

they raise dopamine amounts which produces psychosis similar to schizophrenia

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11
Q

most important dopamine receptor?

A

early drugs were D2 antagonists - this receptor is involved in the production of schizophrenia

these drugs were not very clean, and did a lot which produced more issues

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12
Q

What was the role of atypical antipsychotics?

A

weak D2 antagonist but strong serotonin agonists which remove symptoms - cleaner

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13
Q

anhedonia

A

inability to experience pleasure - people with depression

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14
Q

Depression treatment

A

Imipramine - not effective for schizophrenia - it elevates moods

it amplifies nerve signals sent by serotonin

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15
Q

What is re-uptake? and what happens with serotonin?

A

when nerve cells re-set after each transmission to send more signals.. imipramine blocks serotonin reuptake and amplifies the amount that will be used = higher mood

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16
Q

ipronazid

A

tuberculosis drug
antidepressant effect
inhibition of MAO

17
Q

MAO

A

helps regulate neurotransmitter amounts

so inhibiting it can increase the amount of serotonin in the brain which elevates moods

18
Q

Prozac = SSRI

A

selective serotonin reuptake inhibitor

  • more comfortable - less side effects
19
Q

side effects for depressant drugs

A

anxiety, sleep disturbances, sexual dysfunction, suicidal thoughts

20
Q

OCD

A

obsessive thoughts (unwanted), rituals, magical thinking (thoughts are connected to the rest of the universe)

ex: washing hands 100x a day

21
Q

what drugs can help with OCD?

A

drugs associated with raising serotonin activity

22
Q

Bipolar Disorder

A

personality alternates between states - manic and low

23
Q

what experiment did John Cade do to test for toxin and depression?

A

injected urine from manics into guinea pigs… but they died

so he added a base to the urine and found that lithium calmed manic patients

24
Q

lithium therapeutic window is:

A

very small

25
Q

valproic acid

A

another drug that can be used but its very small and mechanism isn’t known

26
Q

Anxiety

A

person feels fear without reason

27
Q

barbituates

A

GABA agonist

28
Q

Benzodiazapines

A

cleaner drug, amplifies GABA signalling - makes the receptor more sensitive to opening

29
Q

GABA receptor

A

ion channel = valve (allow info to flow through)

30
Q

Valium

A

mothers little helper

31
Q

is a drug similar to the placebo if placebo is 30% effective and drug is 30% effective?

A

No, the drug treatment would still be effective on most people, but considering the amount of people who would have a reaction to the placebo or no treatment

difference between drug and placebo

32
Q

why don’t drugs work better today? why can’t we make them better?

A

cause the brain is just SO complex he hardly know anything about it

33
Q

why are experiments with rats ealier even though their brains are different?

A

we have no full control over humans, difficult to measure brain activity

34
Q

swim despair test

A

put mouse in a container of water, the animal has to swim and after a while it stops swimming - the aount of time is measured and then we give a drig to see if the animal will swim shorter or longer time

35
Q

hotplate test

A

put mouse on a hotplate to test pain to see how long it takes for the animal to lift its feet up

36
Q

me too drug

A

using old drug to find a new drug - to reduce side effects

37
Q
A