Menstrual Disorders Flashcards

1
Q

What is normal menstruation?

A

Age 13-51 from monarch-menopause
Cycle 4-5/21-35
4-5 days bleeding
21-35 cycle length, time from start of one period to start of the next
Menstruation is triggered by a fall in progesterone 2 weeks after ovulation if not pregnant
Mean blood loss 30-40ml

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2
Q

What is menorrhagia?

A

Heavy periods - > 80ml per cycle

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3
Q

What is dysmenorrhoea?

A

Painful periods

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4
Q

What is intermenstrual bleeding?

A

Bleeding between periods

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5
Q

What is postcoital bleeding?

A

Bleeding after sexual intercourse

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6
Q

What is oligomenorrhoea?

A

Infrequent periods e.g. 45-90

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7
Q

What percentage of gynaecology outpatient referrals are accounted for by menstrual abnormality?

A

20%

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8
Q

What percentage of women see their GP with menstrual problems in any year?

A

3% of women aged 30-49

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9
Q

What are the important features of history in a woman with a menstrual problem?

A

Subjective - what is normal for that woman
Clots/flooding - pads and tampons used together, will give an idea of how “heavy”
Pain - with heavy flow or premenstrual, premenstrual may be endometriosis
Ask about effect of symptoms on lifestyle/quality of life

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10
Q

What are the appropriate examinations to do for a woman with menstrual problems?

A

General e.g. anaemic
Abdominal - large fibroids
Speculum - polyps
Bimanual pelvic - size of uterus, adnexal masses

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11
Q

What are the investigations that you might do for a woman with menstrual problems?

A
FBC if menorrhagia 
Endometrial biopsy 
Chlamydia test 
Thyroid/coagulation if other symptoms 
Pregnancy test
Transvaginal US scan 
Hysteroscopy 
Laparoscopy
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12
Q

What are the likely causes of menstrual problems in early teens?

A

Anovulatory cycle
Congenital anomaly
Coagulation problems

Always consider pregnancy and always look at cervix

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13
Q

What are the likely causes of menstrual problems in teens-40s?

A
Chlamydia 
Contraception-related 
Endometriosis/adenomyosis
Fibroids 
Endometrial or cervical polyps 
Dysfunctional bleeding 

Always consider pregnancy and always look at cervix

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14
Q

What are the likely causes of menstrual problems in 40s-menopause?

A
Perimenopausal anovulation 
Endometrial cancer (rare in premenopausal women) 
Warfarin 
Thyroid dysfunction 
Chlamydia 
Contraception-related 
Endometriosis/adenomyosis
Fibroids 
Endometrial or cervical polyps 
Dysfunctional bleeding 

Always consider pregnancy and always look at cervix

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15
Q

According to the FIGO classification, what are the causes of abnormal uterine bleeding?

A

Palm Coe In

P - polyp 
A - adenomyosis 
L - leiomyoma 
M - malignancy 
C - coagulation e.g. Von Willebrand's
O - ovarian e.g. PCO, perimenopausal anovulatory cycles 
E - endocrine e.g. thyroid 
I - iatrogenic e.g. warfarin 
N - not yet classified
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16
Q

What is dysfunctional uterine bleeding?

A

Abnormal uterine bleeding but no structural, endocrine, neoplastic or infectious cause found (yet)

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17
Q

What percentage of women who complain of heavy periods lose < 80ml per cycle?

A

50%

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18
Q

What percentage of hysterectomies are done for dysfunctional uterine bleeding?

A

50%

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19
Q

What is endometriosis?

A

Endometrial type tissue outside the uterine cavity
Usually in ovary, pouch of Douglas or pelvic peritoneum
May be asymptomatic
May resolve without treatment

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20
Q

What kind of bleeding can endometriosis cause?

A

Retrograde bleed

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21
Q

What are the symptoms of endometriosis?

A

Premenstrual pain, particularly 1 week before period starts
Dysmenorrhoea
Deep dyspareunia
Sub-fertility

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22
Q

What are the signs of endometriosis?

A

May be none
Tender nodules in rectovaginal septum
Limited uterine mobility
Adnexal mass

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23
Q

What are the investigations done to diagnose endometriosis?

A

Laparoscopy
MRI
USS endometrioma

24
Q

What is the medical treatment of endometriosis?

A

Progestogen - oral, injection or Mirena IUS, coil will have fewer general side-effects
Combined pill or patch for 3 months (9 weeks) at a time
GnRH analogues e.g. leuprorelin

25
What is the surgical treatment of endometriosis?
Laparoscopic excision of deposits from peritoneum/ovary Diathermy/laser ablation of deposits Hysterectomy alone won't treat endometriosis as ovaries are still there producing hormones, so combined hysterectomy and oophorectomy
26
What is adenomyosis?
Endometrial tissue found deep in the myometrium Heavy painful periods Bulky tender uterus
27
How is adenomyosis diagnoses?
USS - probably normal Laparoscopy - normal Hysteroscopy - normal MRI may suggest diagnosis but limited availability Histology of uterine muscle - not endometrial biopsy
28
What is the treatment of adenomyosis?
Mirena may help | Often failed medical treatment/ablation and diagnosed on pathology at hysterectomy
29
What are fibroids?
Smooth muscle benign tumours - leiomyoma Benign Common, usually asymptomatic
30
What percentage of fibroids are leiomyosarcoma?
0.01%
31
What percentage of 40 year olds have fibroids?
60%
32
In what ethnic group is there a higher incidence/younger age of fibroids?
Afro-Caribbean women
33
How are fibroids diagnosed?
Clinical exam Ultrasound Hysterectomy
34
What are the types of fibroid?
Submucous - protrude into uterine cavity Intramural - within uterine wall Subserous - project out of uterus into peritoneal cavity
35
What are the symptoms of fibroids?
May cause pressure symptoms if large May cause menorrhagia if they cause enlargement of uterine cavity surface area Intermenstrual bleeding if submucous or polyp Asymptomatic May grow fast in pregnancy and cause pain, malpresentation and obstruction
36
What is the treatment of fibroids?
No treatment if incidental finding and asymptomatic Standard menorrhagia treatment if cavity is not too distorted GnRH analogues for temporary shrinkage/preparation Ulipristal oral treatment (antiprogestogen) Transcervical resection of submucous fibroids Myomectomy Uterine artery embolisation Hysterectomy
37
What are the disadvantages of myomectomy?
Risk of haemorrhage and hysterectomy | Need Caesarean section if pregnancy occurs after due to risk of uterine rupture
38
What is the treatment for dysfunctional uterine bleeding?
Reassure patients that there is no sinister pathology Fertility-conserving treatment - non-hormonal or hormonal tablets, progestogen, IUD, Mirena Endometrial ablation or hysterectomy if family is complete
39
What are the fertility conserving treatments?
Tranexamic acid - reduces blood loss by 60% but does not regulate cycle (anti-fibrinolytic) Mefenamic acid - reduces blood loss by 30% and pain but does not regulate cycle (prostaglandin inhibitor) Combined contraception reduces bleeding, pain and regulates cycle Mirena progestogen IUD reduces bleeding (initial 3-4 months irregular bleeding) Oral progestogens e.g. Provera 10mg od, day 5-25 of cycle, reduces bleeding and regulates, day 15-25 may regulate cycle but does not reduce amount of bleeding
40
What is endometrial ablation?
One-off removal of endometrium to below the basal layer Can use diathermy/thermal balloon Not possible if grossly distorted cavity or thin myometrium at CS scar Treatment done through cervix
41
What is the recovery time from endometrial ablation?
approx 1 week
42
What is the effect of endometrial ablation on ovarian hormones and bladder?
No effect
43
What percentage of women following endometrial ablation; - have no periods - are satisfied with treatment - go on to have hysterectomy?
60% have no periods 85% satisfied 15% go on to have hysterectomy
44
What is hysterectomy?
Surgical removal of uterus
45
What are the routes for hysterectomy?
Vaginal or abdominal
46
What are the types of surgical procedures that can be done when performing hysterectomy?
Laparoscopically assisted vaginal hysterectomy Total laparoscopic hysterectomy Laparoscopically assisted subtotal hysterectomy
47
What is a total hysterectomy?
Cervix and uterus removed
48
What is a subtotal hysterectomy?
Uterus removed, cervix left
49
What is a salpingo-oophorectomy?
Removal of Fallopian tubes and ovaries
50
What do you need to do if ovaries are removed?
Immediate menopause - need to give HRT until age 50 to minimise risk of subsequent cancer
51
What symptoms will persist if the ovaries are not removed?
Pre-menstrual symptoms and ovarian pain
52
How many days are spent in hospital after open or vaginal hysterectomy?
3-5
53
How many days are spent in hospital after laparoscopic hysterectomy?
2-3
54
What is the recovery time from hysterectomy?
2-3 months full recovery
55
What are the risks of hysterectomy?
Infection DVT Bladder/bowel/vessel injury Altered bladder function and adhesions