Meningitis Flashcards

1
Q

meningitis in simple terms

A

Inflammation of the meningeal lining of the brain and spine.

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2
Q

the meninges

A

Protect the brain from injury and infection.

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3
Q

Organs that comprise the CNS- brain and spinal cord are covered by three connective tissue layers called the meninges:

A
  1. Pia mater (closest to the brain and spinal cord)
  2. Arachnoid
  3. Dura mater
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4
Q

cerebrospinal fluid

A
  • Flows within the subarachnoid space beneath the arachnoid membrane
  • Maintains constant pressure inside skull- intracranial pressure
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5
Q

how is CSF produced

A

by the choroid plexus

- plasma is filtered from the blood by epithelial cells to produce CSF

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6
Q

characteristics of CSF

A
  • Clear
  • Plasma-like fluid
  • Contains glucose and some protein
  • Few or no cells (cells likely to be lymphocytes)
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7
Q

patient risk factors

A
  • Extremes of age
  • Diabetes mellitus
  • Chronic kidney failure
  • Immunosuppression
    • Cancer
    • HIV
    • Immunosuppressants
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8
Q

bacteria that most often cause meningitis

A
  • Neisseria meningitidis
  • Streptococcus pneumoniae
  • Haemophilus influenzae
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9
Q

virus that most often cause meningitis

A

Cocsackie viruses A and Be

Herpes: HSV 1 and 2

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10
Q

fungus that most often cause meningitis

A

cryptococcus

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11
Q

Viral meningitis is the most

A

common and least serious type.

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12
Q

patient symptoms

A
  • Non-blanching purpuric rash (using glass or tubler test)
  • Stiff neck (nuchal ridigity)
  • Confusion
  • Photophobia
  • Drowsiness
  • Increased pulse rate
  • Aching muscle and joints
  • Being sick
  • Headache
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13
Q

mechanism of infection

A

When pathogen gets into your bloodstream from your sinuses, ears or throat. Pathogen travel through. Bloodstream to brain.

Haemophilus influenza and Meningococcal meningitis can spread via respiratory droplets

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14
Q

prevention

A

vaccinations
Men A
Men B
Men ACWY

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15
Q

prophylaxis

A

for people who have been in close contact

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16
Q

to get a CSF culture

A

lumbar puncture

17
Q

how to take a lumbar puncture

A
  • Spinal cord ends at L1, below this level the nerve roots of the cauda equina float in CSF
  • Needles passed between the spinous process of two adjacent lower lumbar vertebrae to enter the spinal canal by puncturing the dura
  • Small amount of CSF remove and sent to lab
18
Q

normal CSF

A
  • clear
  • WBC <5 CELLS/UL
  • protein <0.4
  • GLUCOSE 2.6-4.6 mol/l
19
Q

bacteria CSF

A
  • often cloudy
  • increased WBC >5-500
  • neutrophils dominant
  • increased protein
  • low glucose
20
Q

tuberculous meningitis

A
  • clear/ cloudy
  • increased WBC 5-1000
  • lymphocytes
  • moderate protein increase
  • glucose normal/ slightly decreased
21
Q

viral meningitis

A
  • clear
  • increased WBC 5-1000
  • lymphocytes
  • moderate protein increase
  • glucose normal
22
Q

fungal meningitis

A
  • clear/cloudy
  • increased WBC 5-500
  • lymphocytes
  • protein increased
  • glucose low
23
Q

antibiotics

A

ceftriaxone (cephalosporin) IV 2g every 12 hours

24
Q

if pt severely ill

A

do not wait for lumbar puncture give ceftriaxone

25
Q

outcome of infection

A
  • Brain swelling
  • Permanent disability
  • Coma
  • Death
  • Sepsis
  • Complete resolution