Hepatitis B Flashcards
1
Q
acute hepatitis
A
- Incubation 6wks- 6months
- AST/ALT in 100s
- 50% have no symptoms
- Clear infection within 6 months
x
2
Q
Only becomes chronic in
A
<10% of infected adults (90% of infected in infancy)
3
Q
chronic hepatitis
A
Persistence of HBsAg after 6 months
25% chronic infection leads to cirrhosis and 5% will develop hepatocellular carcinoma
4
Q
HepB virus
A
DNA
Enveloped
![](https://s3.amazonaws.com/brainscape-prod/system/cm/308/277/788/a_image_thumb.png?1586536060)
5
Q
acute symptoms
A
- Jaundice
- Fatigue
- Abdominal pain
- Anorexia/ nausea/ vomiting
- Arthralgia- pain in joints
6
Q
patient risk factos and mechanism of infection
A
- Vertical transmission (75%)
- Sexual contact
- People who inject drugs
- Close household contacts- significant blood exposure
- HCW via needlestick injury
7
Q
diagonis of infection
A
- HBsAg (surface antigen) appears first
- Next HBeAg (e-antigen) appears – highly infections
- Then first antibody produced- HbecAg (core)
- IgM- early
- IgG-later on
- Followed by e-antibody HBeAb
- Lastly Surface antibody HBsAg appears
- Clearance of virus
- Core antibody HBc persists for life
![](https://s3.amazonaws.com/brainscape-prod/system/cm/308/278/677/a_image_thumb.png?1586536183)
8
Q
Antigne and antibody pattern for the type of infection
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/308/279/344/a_image_thumb.png?1586536210)
9
Q
other diagnostic test
A
can also do HBV DNA (PCR)
10
Q
Treatment of chronic HepB
A
- Life-long anti-virals to suppress viral replication
- Not required for everyone e.g. inactive carrier
- Low VL
- Normal LFTs
- No liver damage
11
Q
Prevention e.g. Vaccination
A
- Genetically engineered surface antigen
- 3 doses + booster if required
- Effective in most people
- Produces surface antibody response
- >10 adequate
- >100 long-term protection
12
Q
Outcome of infection
A
- Can persist to a chronic illness
- No cure- integrates into host genome
13
Q
A