MEN

Question 1

MEN can be subdivided into MEN1 and MEN2a/2b.

What gene is mutated in MEN1 and what is mutated in MEN2a/2b?

Answer 1

MEN1 - MEN1 gene

MEN2a/2b - RET gene

Question 2

What pattern of inheritance does MEN have?

Answer 2

Autosomal dominant

Question 3

What does MEN cause?

Answer 3

Endocrine tumours in various endocrine glands

Question 4

What tumours are associated with:
MEN1
MEN2a
MEN2b

Answer 4

MEN1 (3Ps)

• Parathyroid
• Pancreatic
• Pituitary

MEN2a (2Ps)

• Pheochromocytoma
• Parathyroid adenoma
• MEDULLARY THYROID CANCER

MEN2b
- Phaeochromocytoma

Question 5

What form of MEN presents with neuromas on mouth and lips?

Answer 5

MEN2b

Question 6

Rarely do people with MEN2a get medullary thyroid cancer. T/F?

Answer 6

F

- almost everyone with MEN2a gets medullary thyroid cancer

Question 7

What does medullary thyroid cancer cause an increase in?

Answer 7

Calcitonin - reduced calcium in blood

Question 8

MEN1 can cause pituitary adenomas, which can obviously cause local problems if they grow too big but they can also be functioning adenomas.

What is the two most common hormones to be secreted by functioning adenomas, what would this lead to?

Answer 8

GH and prolactin

Prolactin

• gyneacmastia
• galactorrhea

GH

• acromegaly
• gigantism

Question 9

How is MEN managed?

Answer 9

If MEN2 - remove thyroid to prevent medullary thyroid cancer

If MEN1 - remove troublesome tumours

Question 10

How is MEN diagnosed?

Answer 10

Genetic screening