Memorise

Question 1

Non-myelinated

Answer 1

1Mm
Slow continuous
Speed 1m/sec

Question 2

Myelinated

Answer 2

Diameter 5-10Mm
Fast, salatory, discontinuous
Speed 20-100m/s

Question 3

Conc of K and Na in and out

Answer 3

Na+ in = 15
Na+ out = 150
K+ in = 100
K+ out = 5

Question 4

Antibody structure of chains and how many domains of each. What are the two regions?

Answer 4

2 domains in light and 4-5 heavy. L-ss-H-ss-H-ss-L. Disulfide bonds.
The effector (constant) region = Fc receptors and C1.
Variable region is where antigen binds.

Question 5

IgE

Answer 5

High affinity receptor on mast cells

Low serum

Question 6

IgM

Answer 6

Complement and membrane bound

Question 7

IgG

Answer 7

Complement, foetus
High serum

Most common therefore

Question 8

What is receptor potential in sensory neurons?

Answer 8

Depolarisation produced by activation of a sensory receptor.

Question 9

What is CR1 and what does it bind to? How does it initiate phagocytosis?

Answer 9

Myeloid cell receptor.
Binds to C3b.
Cross linking of surface CR’s initiates phagocytosis

Question 10

What happens in FcR mediated phagocytosis?

Answer 10

Antibody binds to antigen, exposing Fc region. Neutrophil comes along and binds to Fc with their FcR receptor

Question 11

What can a B cell become after colonial selection etc?

Answer 11

Plasma or memory cell that waits in lymphoid tissue

Question 12

What is the B cell receptor?

Answer 12

IgM (think structure) + naive

Question 13

Where does the most diversity occur?

Answer 13

CDR3

Question 14

Humans class 1 and class 2

Answer 14

Class 1: ABC

Class 2: DR, DP, DQ

Question 15

Proximal organs

Answer 15

Duodenum, proximal tubule

Question 16

Distal organs

Answer 16

Colon / collecting duct