Membrane Potential

Question 1

Where is K+ higher

Answer 1

inside the cell

Question 2

Where is Na+ higher

Answer 2

outside the cell

Question 3

Where is Cl- higher

Answer 3

outside the cell

Question 4

Is the cell permeable to Ca++?

Answer 4

no. it does not contribute to the resting membrane potential

Question 5

What is the ratio of stuff the Na-K pump, pumps?

Answer 5

3 Na+s out

2 K+s in

Question 6

At resting membrane potential, is the cell at equilibrium?

Answer 6

No. It’s a steady state

Question 7

net charge neutraility

Answer 7

memrane potential is generated by a very small charge imbalance representing few ions. so both sides maintain net charge neutrality

Question 8

what is resting membrane potential primarily determined by

Answer 8

K+ conc

Question 9

Is Vrest closer to EK or ENa+

Answer 9

EK+

Question 10

function of Na+/K+ pump

Answer 10

maintain higher conc of K+ and lower conc of Na+ in the cytoplasm

Question 11

What inhibits the Na+/K+ pump

Answer 11

ouabain

Question 12

Nerst Equation

Answer 12

quantifies equilibrium potential
single ion
relative permeability is not a factor

Question 13

Goldman equation

Answer 13

multiiple ions

relative permeability is a factor

Question 14

What is the conc of free ionized Ca++ in the cytoplasm like

Answer 14

very low

Question 15

where is most intracellular calcium

Answer 15

sER

Question 16

is the membrane usually permeable or impermeable to Ca++ at rest?

Answer 16

impermeable

Question 17

Is Cl_ higher inside or outside the cell

Answer 17

outside