Medications for Myocardial Infarction

Question 1

Aspirin MOA

Answer 1

Inhibits COX enzyme (TXA2) that promotes platelet aggregation

Question 2

Aspirin Therapeutic Use

Answer 2

Ischemic strokes, TIAs, Stable/unstable angina, Acute MI, Previous MI, prevention of MI.

Question 3

Clopidogrel MOA

Answer 3

blocks ADP receptors on the platelet surface - no ADP - no platelet aggregation

Question 4

Clopidogrel Therapeutic use

Answer 4

Thrombotic events

Question 5

Clopidogrel Considerations

Answer 5

Needs about ~5 days off prior to surgery to wear off in body

Question 6

GPIIB/IIIA R Antagonist - abciximab

Answer 6

IV ONLY
“Super aspirins”
Used for acute coronary syndromes

Question 7

Thrombolytics/Fibrinolytics - Transplasminogen alteplase MOA + Use

Answer 7

Removes already formed clot - given IV
Used for Stroke, MI, MASSIVE PE

Question 8

Thrombolytics/Fibrinolytics - Transplasminogen alteplase - Contraindictions

Answer 8

MANY - patient specific - VERY cautious
Recent internal bleeding of ANY kind, known IC issues, active internal bleeding