Medications for Hyperlipidemia

Question 1

HMG-CoA Reductase Inhibitors end in?

Answer 1

-statin

i.e., Atorvastatin (lipitor)

Question 2

HMG-CoA Reductase Inhibitors Side Effects

Answer 2

Muscle soreness, HA, Rash, GI disturbances, myopathy, rhabdomyolysis (elevated Creatinine Kinase levels - muscle destruction), new- onset diabetes, cataracts

Question 3

HMG-CoA Reductase Inhibitors Drug Interactions

Answer 3

Other lipid lowering drugs
Drugs that inhibit CYP3A4 levels

Question 4

When does cholesterol synthesis occur and when is the best time to take these medications?

Answer 4

Nighttime, so give in the evening

Question 5

Ezetimibe MOA

Answer 5

Interferes with cholesterol absorption and reabsorption of cholesterol in the bile

Thus decreasing TC, LDL, and TGs, apolipoprotein B.

Question 6

Ezetimibe Interactions

Answer 6

Monitor LFTs if used with a statin

Question 7

Bile Acid Sequestrants

Answer 7

Used for LDL Cholesterol reduction

Used for rebound cholesterol elevation - binding cholesterol in gut and prevent it from absorption

Question 8

Fibric Acid Derivatives (Fibrates)

Answer 8

Most effective drug for lowering TG levels

Gemfibrozil (Lopid)

Question 9

Gemfibrozil (Lopid)

Answer 9

Effects on plasma lipoproteins
Affects PPAR alpha receptor
Interacts with warfarin from knocking it off of plasma albumin - measure INR

Question 10

PCSK-9 Inhibitors

Answer 10

Biologic monoclonal antibodies

Drops LDLs by binding to it and decreasing reabsorption