Medications Acting on the RAAS System

Question 1

ACE Inhibitors (ACEI) end in?

Answer 1

-pril

Question 2

ACEI MOA

Answer 2

Reduce levels of angiotensin II and increase levels of bradykinin

Question 3

ACEI Therapeutic Uses

Answer 3

HTN
HF
MI
Diabetes
Nephropathy
Prophylaxis of cardiac patients

Question 4

Decreasing Angiotensin II does what with ACEI?

Answer 4

Vasodilation, decrease blood volume, potassium retention, decrease cardiac and vascular remodeling

Question 5

Increasing Bradykinin does what with ACEI?

Answer 5

Cause vasodilation, increase coughing, and potentially (yet rarely) cause angioedema

Question 6

ACEI Side Effects

Answer 6

HYPOTENSION (first dose)
Hyperkalemia
Cough
Angioedema
Fetal Injury

Question 7

ACEI Drug Interactions

Answer 7

Diuretics
ANY Antihypertensive Agent
Drugs that INCREASE POTASSIUM
Lithium
NSAIDS

Question 8

ARBs MOA

Answer 8

Blocks access of angiotensin II causing dialation of arterioles and veins, reducing excretion of potassium, aldosterone, increasing renal excretion of water and sodium

DOES NOT INHIBIT KINASE II (NO BRADYKININ) = NO COUGH

Question 9

ARBs end in?

Answer 9

-sartan

Question 10

Therapeutic use of ARBs

Answer 10

HTN
HF
Diabetic nephropathy (can prevent too)
Patients that cannot tolerates ACEI

Question 11

ARBs Side Effects

Answer 11

Angioedema
Renal Failure
Fetal Injury

NO cough r/t NO BRADKININ INCREASE

Question 12

Direct Renin Inhibitors MOA

Answer 12

Completely block renin release decreasing the cleavage of angiotensinogen to angiotensin I

Question 13

Direct Renin Blockers end in?

Answer 13

-ren

Question 14

Direct Renin Inhibitor Side Effects

Answer 14

Angioedema
Cough
GI effects
Hyperkalemia
Fetal Injury and death

Question 15

Aldosterone Antagonists MOA

Answer 15

selective blockade of aldosterone receptors decreasing effects