Calcium Channel Blockers Flashcards
Calcium Channel Blockers MOA
Block calcium from entering the cell that stimulate smooth mm. contraction (arterioles of periphery and heart).***
CCBs Therapeutic Uses
HTN
Angina
Cardiac Dysrhythmias - SVT
CCB Medication & Classes
Verapamil (Phenylalkyamines)
Nifedipine (Dihydropyridines)
Diltiazem (Benzothiazepines)
CCBs - Dihydropyridines
Nifedipine
Isradipine
Amlopidine
CCBs - Nondihydropyridines
Phenylakylamines - Diltiazem
Benzothiapines - Verapamil
Verapamil and Diltiazem MOA
Blockade at peripheral arterioles = dilation = decreasing arterial blood pressure
Increasing coronary perfusion via dilation
SA node conduction decreases lowering heart rate
AV node decreases lowering nodal conduction
Myocardium decreases lowering force of contraction
Diltiazem & Verapamil Therapeutic uses
HTN
Angina
Dysrhythmias*** - can cause severe CV effects too if used for dys
Verapamil & Diltiazem Side Effects
Number 1 Complaint is constipation!!!!***
Dizziness
Facial flushing
HA
Edema
Heart blocks
Verapamil & Diltiazem Drug interactions
Digoxin + Beta Blockers
Verapamil & Diltiazem Toxicity Signs
Severe HYPOtension
Bradycardia and AV Blocks
V-tach
Dihydropyridines - nifedipine
Agents act mainly on vascular smooth mm. in arterioles by blocking calcium influx
Minimal blockage of calcium channels, cannot be used to treat dysrhythmias, does not cause cardiac suppression
Consider reflex tachycardia as they only work at the arteriole level
Dihydropyridines Therapeutic Uses
HTN
Angina pectoris
Dihydropyridines Side Effects
Low & Slow = dizziness, fainting, edema, HA
Gingival hyperplasia
Chronic eczematous rash
