Calcium Channel Blockers Flashcards
Calcium Channel Blockers MOA
Block calcium from entering the cell that stimulate smooth mm. contraction (arteriolies).***
CCBs Therapeutic Uses
HTN
Angina
Cardiac Dysrhythmias
CCB Medications
Verapamil
Nifedipine
Diltiazem
CCBs - Dihydropyridines
1st Generation - Nifedipine
2nd Generation - Isradipine
3rd Generation - Amlopidine
CCBs - Nondihydropyridines
Phenylakylamines - Diltiazem
Benzothiapines - Verapamil
Verpamil and Diltiazem MOA
Blockade at peripherhal arterioles = dialation = decreasing arterial blood pressure
Increasing coronary perfusion via dilation
SA node conduction decreases lowering heart rate
AV node decreases lowering nodal conduction
Myocardium decreases lowering force of contraction
Diltiaem & Verapamil Therapeutic uses
HTN
Angina
Dysrhythmias
Verapamil & Diltiazem Side Effects
1 Complaint is constipation!
Dizziness
Facial flushing
HA
Edema
Heart blocks
Verapamil & Diltiazem Drug interactions
Digoxin + Beta Blockers
Verapamil & Diltiazem Toxicity Signs
Severe HYPOtension
Bradycardia and AV Blocks
V-tach
Dihydropyridines - nifedipine
Agents act mainly on vascular smooth mm. in arterioles by blocking calcium influx
Minimal blockage of calcium channels, cannot be used to treat dysrhythmias, does not cause cardiac suppression
Consider reflex tachycardia as they only work at the arteriole level
Dihydropyridines Therapeutic Uses
Angina pectoris
HTN
Dihydropyridines Side Effects
Gingival hyperplasia
Chronic eczematous rash
