Medications/DMARDs

Question 1

name the 6 drug families that are given for ischaemic heart disease

Answer 1

1. ACE inhibitors
2. Statins
3. B-blockers
4. Calcium channel blockers
5. nitrates
6. others ie nicorandil

Question 2

5 drug families given for hypertension

Answer 2

1. ACE inhibitors
2. angiotensin 2 receptor antagonists
3. B-blockers
4. Calcium channel blockers
5. Diuretics

Question 3

what are the 4 drugs given for heart failure?

Answer 3

• ACE inhibitors/angiotensin 2 receptor antagonists
• B-blockers
• diuretics
• digoxin

Question 4

what medication id given in valvular disease?

Answer 4

anticoagulants

Question 5

what medications are given for arrythmias?

Answer 5

• Anti-coagulants
• B-blockers
• Calcium agonists
• Digoxin
• Amiodarone

Question 6

what 3 types of drugs can give MRONJ?

Answer 6

• bisphosphonates
• denosumab
• anti-angiogenics

Question 7

name 2 anti-angiogenics

Answer 7

1. sunitinib

2. bevacizumab

Question 8

what are anti-angiogenics given for?

Answer 8

as cancer tx (esp if bone metastases)

Question 9

what are some of the oral effects of anti-angiogenics (3)

Answer 9

• taste d
• oral mucositis
• vomitting

Question 10

what is denosumab given for?

Answer 10

• postmenopasal women with osteoporosis
• men with prostate cancer at risk of fractures
• bone metastases

Question 11

what are the 5 medication groups that are given to patients with asthma?

Answer 11

• short acting B-2 agonist
• long acting B-2 agonist
• steroid
• anti-leukotrienes
• systemic steroids

Question 12

name a systemic steroid?

Answer 12

• prednisolone

Question 13

what are all the main uses for prednisolone?

Answer 13

• asthma
• COPD
• rheumatoid arthritis
• SLE
• giant cell (temporal) arteritis
• prophylaxis of episodic cluster headaches
• ulcerative colitis
• chrons disease

Question 14

what (in addition to all the asthma drugs) are taken for COPD?

Answer 14

• short acting muscarinic antagonists (ipatropium)
• long acting muscatinic antagonists (tiotropium)
• mucolytic (carbonaisteine)
• antibiotics (azithromycin)

Question 15

name 2 corticosteroid drugs

Answer 15

1. hydrocortisone

2. triamcinolone

Question 16

what are the 2 possible side effects of corticosteroids that require monitoring>

Answer 16

• BP changes

- hyperglycaemia

Question 17

what are some oral effects of corticosteriods?

Answer 17

• candidosis

- MRONJ

Question 18

what are 2 diseases that can occur due to taking corticosteroids?

Answer 18

• cushing syndrome

- osteoperosis

Question 19

name some DMARDs

Answer 19

• methotrexate
• ciclosporin
• hydrochloroquine
• azathiopine
• sulfasalazine
• gold
• lefunomide
• myocophenolate mofietil

Question 20

2 ways methotrexate can be delivered are?

Answer 20

orally

subcutaneous injection

Question 21

2 ways that azathiopine can be administered are?

Answer 21

orally

intravenously

Question 22

what is the dose of methtrexate given?

Answer 22

7.5 - 15mg (max is 25mg)

taken 1x a week

Question 23

what is the dose of azathipine given?

Answer 23

1-3mg/kg

Question 24

what are the dental aspects of DMARDs?

Answer 24

• oral ulceration

- neutropenia ( increased susceptibility to infection)

Question 25

what patients will receive biologics - monoclonal antibody therapy?

Answer 25

those who have failed to respond to at lease 2 DMARDs