Medications Flashcards
P450 Inducers
carbamazepine
rifampacin
st johns wor
smoking - if having cessation consider reducing some drug doses
chronic alcohol intake
barbituates
phenytoin
P450 inhibitors (drugs stay in system longer)
ciproloxacin
erythromycin
isoniazid
omeprazole
amiodarone
allopurinol
imidazoles
fluoxertine, sertraline
sodium valproate
acute alcohol intake
what medication can reduce efficacy of COCP?
ella one wait for 5 days before restarting
carbamazepine
causes pancreatitis
pioglitazones
azathioprine
thiazides
oestrogen containing contraception
steroids
Flucloxacillin + cocp
Causes cholestasis
Allergic Adrenaline
For anaphylaxis the correct dose for adrenaline 1:1000 is:
For children 1 month-5 years: 150mcg (or 0.15ml)
For children 6-11 years: 300mcg (or 0.3ml)
For children > 12 and adults: 500mcg (or 0.5ml)
PPI
hyponatraemia, hypomagnasaemia
osteoporosis → increased risk of fractures
Beta blockers
Beta-blockers reduce hypoglycaemic awareness
Causes sleep disturbances including nightmares
Morphine
30mg = fentanyl 12
60mg = fentanyl 25
Oral morphine divide by 3 for subcut diamorphine/oxycodone
Oral oxycodone divide by 1.5 for subcut diamorphine
Opioid induced n&v use haloperidol and metoclopramide
Hyoscine butylbromide
Anticholinergic effect so dry mouth urinzry retention
Used for secretions and obstructed bowel in end of life
Cyclizine
End of life good for vestibular n&v or with Dex for intracranial tumourz
disulfram
for alcohol dependence
CI in coronary artery disease
acomprosate
reduce cravings for alcohol
CI in renal impairment
bupropion
used for smoking cessation
CI eating disorder
epilepsy
pregnancy
urine drug test
cannabis and benzos stay in urine for up to 3-6 wks
seizures
common in alcohol and benzo withdrawal
smoking cessation in pregnant
1st line CBT
2nd line nicotine replacement therapy
perindopril
bioavailability lowers as we age so reduced effect
british pharmaceutical industry
responsible for the regulation of the promotion of prescribed drugs from pharmaceutical companies
caldicott guardian
protects a persons confidentiality
anastrozole
used for breast ca
reduced circulating oestrogel levels - predispose to reduced bone density and fractures
sensivity to NSAIDs in asthmatis
risk factors are nasal polyps, chornic nasal congestion, female middle age
African BG HTN
First line CCB
2nd line add ARB (not ACE)
Pioglitqzome
Ci in bladder cancer + HF
causes weight gain + fluid retention
Methotrexate
Give folic acid 5mg once weekly 24hrs after methotrexate
T2DM Black wit HTN
An angiotensin II receptor blocker should be used first-line for black TD2M patients who are diagnosed with hypertension
iron/calcium tablets
Iron / calcium carbonate tablets can reduce the absorption of levothyroxine - should be given 4 hours apart
cytotoxic medication SE
-bleomycin lung fibrosis
-doxorubicin cardiomyopathy
-cyclophosphamide haemorrhaghic cystitis
-methotrexate lung + liver fibrosis
-cytarabine ataxia
-gold protenueira
sulfasalazine - reduced sperm
b12 deficiency
precipitated by metformin and PPI
drug urine
cannabis 1 month
benzos 1 wk
methadone 1-2 days but 1 week if maintenance
cocaine + opiates 3 days
sildenafil
CI in recent MI within 6 months or nitrates
