Medications

Question 1

P450 Inducers

Answer 1

carbamazepine
rifampacin
st johns wor
smoking
chronic alcohol intake
barbituates

Question 2

P450 inhibitors (drugs stay in system longer)

Answer 2

ciproloxacin
erythromycin
isoniazid
omeprazole
amiodarone
allopurinol
imidazoles
fluoxertine, sertraline
sodium valproate
acute alcohol intake

Question 3

what medication can reduce efficacy of COCP?

Answer 3

ella one
carbamazepine

Question 4

causes pancreatitis

Answer 4

pioglitazones
azathioprine
thiazides
oestrogen containing contraception
steroids

Question 5

Flucloxacillin

Answer 5

Causes cholestasis

Question 6

Allergic Adrenaline

Answer 6

For anaphylaxis the correct dose for adrenaline 1:1000 is:
For children 1 month-5 years: 150mcg (or 0.15ml)
For children 6-11 years: 300mcg (or 0.3ml)
For children > 12 and adults: 500mcg (or 0.5ml)

Question 7

PPI

Answer 7

hyponatraemia, hypomagnasaemia
osteoporosis → increased risk of fractures

Question 8

Beta blockers

Answer 8

Beta-blockers reduce hypoglycaemic awareness

Causes sleep disturbances including nightmares

Question 9

Morphine

Answer 9

30mg = fentanyl 12
60mg = fentanyl 25
Oral morphine divide by 3 for subcut diamorphine
Oral oxycodone divide by 1.5 for subcut diamorphine

Opioid induced n&v use haloperidol and metoclopramide

Question 10

Hyoscine butylbromide

Answer 10

Anticholinergic effect so dry mouth urinzry retention
Used for secretions and obstructed bowel in end of life

Question 11

Cyclizine

Answer 11

End of life good for vestibular n&v or with Dex for intracranial tumourz