Medically important fungi Flashcards

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1
Q

What are fungal diseases known as?

A

Mycoses

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2
Q

What are the 5 types of fungal infections?

A
  1. Superficial
  2. Cutaneous
  3. Subcutaneous
  4. Systemic
  5. Opportunistic
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3
Q
  • Superficial myscoses infect:
  • How do they typically infect?
A
  • Skin and hair
  • Direct contact
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4
Q

Malassezia furfur

  • Where does it live?
  • What disease does it cause?
A
  • Lives in epithelial cells
  • Pityriasis versicolor
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5
Q

What are the symptoms of pityriasis versicolor?

A

Hypopigmentation

Destroys malanocytes (pigment cells)

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6
Q

Trichophyton rubrum

What diseases does it cause?

What part of the body does it infect?

How is it contracted?

A
  • Tinea diseases: Ringworm, jock itch, athlete’s foot
  • Infect deeper Keratinized layers
  • Direct contact
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7
Q
  • How do subcutaneous fungi typically infect?
  • What type of disease are they?
A

Direct contact through traumatized skin

Chronic condition

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8
Q

Sporothrix schenckii

  • What disease does it cause?
  • Where does it travel throughout the body?
A
  • Sporotrichosis (rose gardener’s disease)
  • Travels in lymphatic system
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9
Q

What are the signs of sporotrichosis?

A
  • Makes hard nodules
    • Become necrotic
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10
Q

What are systemic mycoses?

  • In what form do they present themselves?
  • How are they acquired?
A

Found in multiple parts of body

  • Usually dimorphic (hyphae to yeast)
  • Usually infect by inhalation of spores
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11
Q

Histoplasma capsulatum

What disease does it cause?

Where does it grow?

A
  • Histoplasmosis
  • Grows in lung macrophages then goes systemic
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12
Q

What are the signs of histoplasmosis?

A

Lesions of brain, intestine, heart

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13
Q

Cryptococcus neofromans

  • What disease does it cause?
  • Where is it typically found?
  • How does it infect?
A
  • Cryptococcosis
  • Found in bird droppings
  • Inhaled then escapes to blood
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14
Q

What are the signs of cryptococcosis?

A
  • Meningitis
  • tumor-like masses of brain
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15
Q

How do opportunistic mycoses infect?

A

Part of normal flora

Take advantage when person is immunocompromised

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16
Q

Aspergillus

What disease does it cause?

How does it form in the body?

A
  • Pulmonary aspergillosis
  • Colonies form in lungs then spread to organs
17
Q

What are the signs of aspergillosis?

A

Aspergillomas

Fungal balls in lungs

18
Q

Candida

What is the shape of the fungus?

What diseases does it cause?

A
  • Change from yeast to hyphae
  • Candidiasis (multiple types)
19
Q

What do these types of Candidiasis cause:

  • Mucosal candidiasis
  • Cutaneous candidiasis
A
  • Thrush- Infection of mouth
  • Rash where skin folds
20
Q

When do Vaginal candidiasis typically infect?

A

After disruption of normal lactobacillus

21
Q

Pneumocysria jiroveci

  • When does it occur?
  • How does it infect?
  • What does it do?
A
  • Only in immunocompromised patients
  • Inhaled into lungs
  • Fills alveoli with exudate (aspyxiation)
22
Q

What are the methods (3) for antifungals that target plasma membrane?

A
  1. Disrupt plasma membrane (highly toxic for humans)
  2. Disrupt ergosterol synthesis
  3. Disrupt ergosterol enzymes
23
Q

What types of infections do these antifungals treat:

  • Disrupt ergosterol synthesis
  • Disrupt ergosterol enzymes
A

Synthesis= Systemic/local infections

Enzymes= topical infections

24
Q

What type of infection do these antifungals treat?

  • cell division
  • Nucleic acid synthesis
A
  • Cell division= Skin/nail infections
  • Nucleic acid synthesis= Systemic infections
25
Q

How do antifungals that target the cell wall work?

A

Block polysaccharide synthesis