Medically Important DNA Viruses Flashcards
1
Q
What are the genomes like for:
- Enveloped viruses
- Nonenveloped viruses
A
- Only double stranded
- Can be double or single stranded
2
Q
Review: What makes up a (1)non-enveloped virion? (2)Enveloped?
A
- nucleocapsid + genome
- Nucleocapsid + genome + lipid membrane
3
Q
Poxvirus
- Enveloped or non-?
- What is its target?
- Site of replication?
- symptoms?
A
- Enveloped (dsDNA)
- targets Epidermal cells
- replicates in cytoplasm
- cause eruptive skin pustules
4
Q
Poxvirus: Variola virus
- disease
- how is it transmitted?
- how does it manifest?
A
- small pox
- inhaled droplets, contact with pustule liquid
- fever, rash, pustules
5
Q
Poxvirus: Molluscum contagiosum
- transmitted?
- symptoms?
A
- direct contact with lesion
- small raised pinkish lesion with dimple (children 1-6)
6
Q
Herpesvirus
- enveloped or non-?
- latent or acute?
- replicates where?
A
- dsDNA and enveloped
- latent, causing recurrent infection in times of stress
- replicates in nucleus and becomes episome (reside in nucleus and neurons)
7
Q
Herpes Simplex virus(HSV) HSV1
- transmitted?
- symptoms
- Latency?
A
- direct facial contact
- creates lesions on oropharynx (cold sores)
- resides in trigeminal ganglion
8
Q
HSV2
- transmitted?
- symptoms?
- Latency?
A
- sexual contact (direct)
- creates lesions on genitalia
- resides in sacral ganglion
9
Q
Herpesvirus: Varicella zoster virus
- diseases (2)
- transmitted
- symptoms
- latency
- cure?
A
- chicken pox, later turn into shingles
- inhaled droplets or skin lesion fluid
- small itchy lesions
- stays in spinal ganglion
- live attenuated vaccine available
10
Q
Herpesvirus: Cytomegalovirus
- diseases(2)
- transmitted
- latency?
A
- Congenital CMV
- CMV mononucleosis
- saliva, mucus, milk, urine, etc.
Remains latent in white blood cells
11
Q
What are these types of CMV common in:
- Congenital CMV
- Mononucleosis
- Who does CMV infect
- What are the symptoms?
A
- Congenital- Affects newborns (can be fatal)
- Mononucleosis- Adults
- only affect immune deficient
- jaundice, enlarged organs
12
Q
Herpesvirus: Epstein-Barr virus
- diseases
- transmitted
- latency
A
- Mono and Burkitt lymphoma
- direct oral contact or contact with saliva
targets epithelium of oropharynx, replicates in parotid gland -stays in B-cells*****
13
Q
- What tissue does Epstein-Barr virus target?
- Where does it replicate?
A
- targets epithelium of oropharynx
- replicates in parotid gland
14
Q
Hepatitis -infects
**-DNA or RNA virus (will be on test)
-transmitted -symptoms -vaccine?
A
- infects the liver
- HepB is the only DNA virus, A,C, and D are RNA****
- transmitted through sexual contact or contact with blood (IV/transfussion)
15
Q
What are the symptoms of hepatitis?
Is there a cure?
A
- healthy person has no symptoms and develop immunity (liver regeneration*)
- HepB surface antigen vaccine available
