Med Chem of AntiMalarials & Antiparasitics Flashcards
1
Q
Chloroquine / Hydroxychloroquine
A
- MoA: accumalate in food vacoule; inhibits heme polymerization
2
Q
Chloroquine, Quinine, and Primaquine - AE
A
HIGH risk of hemolysis in pts w/ G6PD deficiency
3
Q
How is Lice transmitted? What pop is most frequently infected?
A
- Transmitted by direct touch
- Kids 3-11y.o get infected frequently
4
Q
What organisms cause relapsing malaria
A
- Plasmodium Vivax
- Plasmodium Ovale
5
Q
Spinosad - SoA, MoA
A
- Pediculosis (Lice)
- Rx
- MoA: rapid excitation of the insect nervous system causes death
6
Q
what organisms cause the most malaria infxns
A
- Plasmodium Falciparum
- Plasmodium Vivax
7
Q
Albendazole
A
- broad spectrum
- MoA: bind to tubulin; inhibits formation of microtubules
- D.O.C for pinworms
- avoid in pregnant women
8
Q
Doxycycline
A
- targets components of the apicoplast
9
Q
Pyrantel Pamoate
A
- broad spectrum
- OTC
- MoA: depolarizing neuromuscular blocking agent (releases AChE and inhibits cholinesterase); worms are paralyzed
- used for pinworms and Ascariasis
10
Q
Primaquine
A
- D.O.C for Liver Stage (hyponozoite) of P. Vivax in combo/ Chloroquine
- activated by metabolism of CYP2D6
- MoA: may involve free radicals and H2O2
11
Q
How are Pinworms (helminth) transmitted? What pop is most frequently infected
A
- Transmitted by fecal-oral
- School age kids (5-10y.o), institutionalized pts, and household members/caretakers of someone who has it
12
Q
Artemisinin
A
- Key functional group: endoperoxide
- MoA: maybe forms free radicals, maybe inhibits PfPI3K
13
Q
Pyrethrin & Permethrin - SoA, caution
A
- OTC
- Pediculosis (lice)
- caution if Hx of ragweed or chrysantheum Ax
