Clinical Antifungals Flashcards
1
Q
Tx of Oropharyngeal Candidiasis (thrush)
A
- Mild: Topical (clotrimazole troche or nystatin susp)
- Systemic Tx needed: Fluconazole 100 qd
- Refractory/Fluc Resist: Itraconazole solution x ≥14d (max 28)
- Tx for 7-14d
2
Q
Ibrexafungerb - CI
A
CI in pregnancy
3
Q
Itraconazole - SoA, AE, Indication
A
- Histo, Blasto
- 1st line: histo
- AE: Hepatotoxic, QTc prolong
4
Q
Fluconazole - SoA, AE, Indication
A
- 1st line: Candida Alb, C. Parap, C. Trop, C. lusit, Coccidiodes
- AE: QTc prolong
5
Q
Caspofungin - AE
A
AE: rash, puritis, fever, inc K, inc LFTs
6
Q
Isavuconazole - pearls
A
- least D-I of all Azoles
- SHORTENS QTc
7
Q
Posaconazole - SoA/CI
A
- avoid if CrCl <50
- asperigillus
8
Q
Micafungin - AE
A
AE: inc bilirubin, N/D
9
Q
Voriconazole - SoA, AE, Indication
A
- 1st line: Aspergillus
- avoid IV if CrCl <50
10
Q
Amphotericin B - SoA, AE, Indication
A
- 1st line: Crypto, Blasto, Histo systemic infxns
- AE: Nephrotoxic (inc SCr, BUN), Lyte Abnorm (dec K/Mg)
11
Q
Flucytosine - SoA, AE, Indication
A
- 1st line: Cryptococcus
- usually in combo w/ AmboB
- AE: bone marrow suppression
- monitor: CBC, platelets, Scr, BUN
12
Q
Tx of Esophageal Candidiasis
A
- Fluconazole 200 PO/IV qd
- Tx for 14-21d
13
Q
Echinocandins - SoA/Indications
A
1st line: Candida GLABATRA, C. Krusei, C. Lusit, C. Auris
