Medicinal Chem of Antivirals

Question 1

SoA - Famciclovir/ Penciclovir

Answer 1

HSV1/2 and VZV

Question 2

Grazoprevir MoA

Answer 2

HCV NS3 Protease-i

Question 3

Delavirdine MoA

Answer 3

NNRT-I

Question 4

Oseltamivir MoA

Answer 4

neuraminidase-i

Question 5

SoA - Acyclovir/ Valacyclovir

Answer 5

HSV1/2 and VZV

Question 6

Rilpivirine MoA

Answer 6

NNRT-I

Question 7

SoA/MoA- Ribavirin

Answer 7

• Inhibits IMDDH
• Flu A/B
• Hepatitis A, B, C
• Genital herpes
• herpes zoster

Question 8

Bictegravir MoA

Answer 8

Integrase-i

Question 9

Prodrugs

Answer 9

• Acyclovir (viral enzyme and triphosphorolated)
• Valacyclovir (converted into Acyclovir)
• Famciclovir (converted to Pen by 1st pass metabolism in the intestine/liver)
• Valganciclovir (hydrolyzed to Gan in intestine/liver)
• Cidofovir (phosphorylated by cellular kinase)

Question 10

Tenofovir alafenamide MoA

Answer 10

NRTI

Question 11

Velpatasvir MoA

Answer 11

HCV NS5A-i

Question 12

Ledipasvir MoA/Res

Answer 12

HCV NS5A-i
- 1st gen (high resistance)

Question 13

Sofosbuvir MoA

Answer 13

HCV RNA Polymerase-i (NS5B-i)

Question 14

Glecaprevir MoA

Answer 14

HCV NS3 Protease-i

Question 15

Daclatasvir MoA/Res

Answer 15

HCV NS5A-i
- 1st gen (high resistance)

Question 16

Chain Terminators

Answer 16

• Acyclovir / Valacyclovir
• Ganciclovir / Valganciclovir
• Cidofovir

Question 17

Acyclovir/Val MoA

Answer 17

• inhibits viral DNA polymerase
• chain terminator

Question 18

SoA - Foscarnet, Cidofovir, and Letermovir

Answer 18

CMV

Question 19

Voxilaprevir MoA

Answer 19

HCV NS3 Protease-i

Question 20

Nirmatrelvir MoA

Answer 20

• inhibits SARS-COV-2
• admin w/ Ritonavir (inhibits CYP3A4… inc Nirm levels)

Question 21

Foscarnet MoA

Answer 21

Traps polymerase in closed formation

Question 22

Letermovir MoA

Answer 22

inhibits terminase complex by binding to pUL56 -> prevents cleaving and packaging

Question 23

Etavirine MoA

Answer 23

NNRT-I

Question 24

Darunavir MoA

Answer 24

Protease-i

Question 25

Elbasvir MoA/Res

Answer 25

HCV NS5A-i
- 1st gen (high resistance)

Question 26

Efavirenz MoA

Answer 26

NNRT-I

Question 27

Remdesivir MoA

Answer 27

inhibits viral RNA polymerase

Question 28

Atazanavir MoA

Answer 28

Protease-i

Question 29

HBV-i

Answer 29

• Lamivudine
• Entacavir
• Tenofovir (nucleotide-i)

Question 30

Binding Site of Foscarnet on DNA Polymerase

Answer 30

blocks PYROPHOSPHATE binding site of the viral DNA polymerase

Question 31

Pibrentasvir

Answer 31

HCV NS5A-i

Question 32

Dasabuvir MoA

Answer 32

HCV RNA Polymerase-i (NS5B-i)

Question 33

Lamivudine MoA

Answer 33

NRTi

Question 34

Abacavir MoA

Answer 34

NRTi

Question 35

HCV NS3 Protease-i Resistance Mech

Answer 35

-Res: Mut in NS3 active site (but keep activity against mut to Gen-1 Protease-i)

Question 36

Nevirapine MoA

Answer 36

NNRT-I

Question 37

Atazanavir MoA

Answer 37

Protease-i

Question 38

SoA - Ganciclovir/ Valganciclovir

Answer 38

CMV

Question 39

Emtricitabine MoA

Answer 39

NRTi

Question 40

Dolutegravir MoA

Answer 40

Integrase-i

Question 41

Fam/Pen/Gan/Valgan MoA

Answer 41

competitive inhibitor of DNA polymerase

Question 42

Elvitagravir MoA

Answer 42

Integrase-i
- combo w/ cobicistate (inhibits 3A4… inc elvit concentrations)

Question 43

Cidofovir MoA

Answer 43

chain terminator

Question 44

PI boosting

Answer 44

low doses of Ritonavir inhibits CYP3A4… inc [PI], dec resistance, inc compliance (lower doses and frequency)