Mechanisms of Pathogenesis Flashcards
Chapter 14 and Chapter 15
Define Pathology
scientific study of disease
Define Etiology
Cause of a disease
Define Pathogenesis
How a disease develops (structural/functional)
Define Infection
Invasion/Colonization of the body by a pathogenic microbe
Define Disease
Infection changes the normal status of health
Define Host
Organism that harbors another organism
Define Normal Flora
Permanent, (typically) nonpathogenic microbes
What is resident flora?
Microbes that are always present on/in the human body
What is transient flora?
Microbes that come and go
Do babies in the womb encounter microbes?
No
When do babies begin encountering microbes?
At birth
What common microbes do babies encounter? (2)
- lactobacilli (mother’s vagina)
- feeding and breathing (URT and GIT)
(T/F) There are more cells than bacteria in the body
False, bacteria > cells
Define symbiosis
Association between 2+ species
Example of Symbiosis
Host and Normal Flora
Define Commensalism
One organisms benefits, other organism not affected
Example of Commensalism
Staphylococcus epidermis (on our skin)
Define Mutualism
Both organisms benefit
Example of Mutualism
E. coli in the intestines (produce vitamins for the body)
Define Antagonism
Competition between the microorganisms
Define Competitive Exclusion
Normal Flora vs Pathogen over resources (food)
Example of Antagonism
Bacteriocins in the large intestine (inhibit other bacteria)
Define Parasitism
One organism benefits, other is harmed
Example of Parasitism
Any successful pathogenic microorganism
Describe Probiotics
Live microbial cultures are applied/ingested to benefit the host
Define Opportunistic
Become pathogenic under certain circumstances
What are ways opportunistic pathogens are given opportunity? (3)
- normal flora disrupted/destroyed
- defense mechanisms compromised
- normal protective barriers disrupted
Examples of Opportunistic Pathogens (3)
- S. aureus (TSS)
- Pneumocystis jirovecii (pneumonia in AIDS patients)
- E. coli (UTI if moved to urethra)
Define Symptoms
Changes in body functions (pain and malaise)
Define Signs
VISIBLE changes (rash, fever, swelling)
Define Syndrome
Specific symptoms and signs associated with a disease
Define Infectious
Caused by bacteria, viruses, fungi, protozoa, and helminthes
Define Communicable Infectious Diseases
Contagious (directly or indirectly)
Define Non-Communicable Infectious Diseases
Caused by individual’s normal flora, ingestion or preformed toxins, organisms in the environment (not contagious)
Define Non-Infectious
Caused by any other factor than infectious organisms
Define Incidence
Number of new cases contracted within a set population during a set time period
Define Prevalence
TOTAL number of people infected within a population at ANY time
Define Sporadic
Occurs occasionally in a population
Define Endemic
Disease that is always found in the region
Define Epidemic
Disease that many people acquire in a very SHORT period of time
Define Pandemic
An epidemic that is worldwide
Define Acute Disease
Symptoms develop rapidly, lasts a SHORT time
Define Chronic Disease
Symptoms develop slowly
Define Subacute Disease
Intermediate (between acute-chronic)
Define Latent Disease
Inactive until activation, then produces symptoms
Define Herd Immunity
Immunity in MOST of a population
(T/F) Pathogens can live without a host
False
Define Reservoir
Continual source of the disease causing organisms (living or inanimate objects)
Describe Human Reservoirs (3)
- transmit microorganisms directly/indirectly
- carries (asymptomatic people)
- convalescing patients (gradual recovery)
Describe Animal Reservoirs (3)
- wild and/or domestic
- zoonoses (primarily in animals, possible in humans)
- transmitted: bites, contaminated hides/feathers, food, insect vectors
What are examples of nonliving reservoirs of infection? (2)
- soil (fungal diseases)
- water (feces)
What are the modes of disease transmission (3)
- contact
- vehicle
- vector
Where do pathogens leave the host from?
The same way it came in (portal of entry)
What is direct transmission?
person-to-person
What is congenital transmission?
mother to fetus/newborn
What is indirect transmission?
fomites (nonliving objects)
What is droplet transmission?
coughing, sneezing, talking
What is vehicle transmission?
Through a medium
How is water a vehicle of transmission?
fecal contamination
How is food a vehicle of transmission?
incompletely cooked food or improperly refrigerated foods; food poisoning
How is air a vehicle of transmission?
mucus droplets by droplet nuclei
What are the four vehicles of transmission?
- water
- food
- air
- body fluids and blood
What is vector transmission?
Through an arthropod (insect)
What are two examples of vector transmission?
- biological
- mechanical
What is an example of biochemical transmission?
- bitten by infected insect (lyme disease, malaria)
What is an example of mechanical transmission?
- transfer of microbe from feet or other body parts of insects to food/skin of person
- passive; no replication of microbe within vector (shigellosis, typhoid fever)
What are nosocomial infections?
Acquired in a hospital/medical facility
What are the three factors of nosocomial infections?
- microbe in hospital
- compromised patient
- chain of transmission