Measuring Kidney Function

Question 1

What age do you have a normal GFR number ?

Answer 1

18 months old

Question 2

What age does GFR start to decline?

Answer 2

30 years old

Question 3

Define the concept of clearance

Answer 3

volume of plasma cleared of a substance per unit time, across whole body

Question 4

If flow increases what would happen to renal clearance?

Answer 4

Faster

Question 5

If plasma concentration increases what would happen to renal clearance ?

Answer 5

Slower

Question 6

What are the 4 criteria for a substance to measure kidney clearance ?

Answer 6

Produced at a constant rate, freely filtered across the glomerulus, not be reabsorbed in the nephron and not be secreted into the nephron

Question 7

Which exogenous marker is used in children?

Answer 7

51 Cr-EDTA

Question 8

What endogenous marker is often used in pregnant women?

Answer 8

Creatinine

Question 9

What is eGFR?

Answer 9

The estimation of GFR by creatinine

Question 10

What are the 2 test types for eGFR?

Answer 10

MDRD and CKD-EPI