Measurements and Errors of measurement/Data source & Quality Flashcards
Defining who has the disease
PROBLEMS WITH INCIDENCE AND PREVALENCE MEASUREMENTS:
PROBLEMS WITH NUMERATORS
.Problems due to difficulties in diagnosis
Some Possible Sources of Error in Interview Surveys
- participant may chose not to respond or alter his response
- responds to please the interviewer
Problems associated with the study participant
- not recording or incorrect recording
- incorrect questioning
- biased by knowing the hypothesis being tested and may probe more intensively in one group than in another
Problems associated with the interviewer
- Selective undercounting of certain groups e.g. Ethnic minority
- Different studies use different definitions so comparison of results is difficult
- For a rate of make sense, every one in the group represented by the denominator must have the potential to enter the group represented by the denominator. This is not that simple.
Example: Uterine cancer rates
Hysterectomy
PROBLEMS WITH DENOMINATORS
An index of the severity of a disease from both clinical and public health standpoints
Mortality
Can also be used as an index of the risk of disease
Mortality
Easier to obtain than incidence data for a given disease, however when a disease is mild and not fatal, it is not a good index for incidence
Mortality
2 conditions where mortality rate is a good reflection of incidence rate:
When case-fatality is high (i.e. untreated rabies)
When duration of disease is short (survival)
i.e Pancreatic cancer – where mortality is good surrogate for incidence
the disease or injury which initiated morbid events leading directly or indirectly to death → underlying cause
Cause of death
excludes information pertaining to the immediate cause of death, contributory causes, and those causes that intervene between underlying and immediate causes
Underlying cause of death
Is a true experiment in which patients are assigned randomly to a study category (treatment), and are then followed forward in time, and the outcome is assessed
RANDOMIZED CONTROL TRIAL (RCT)
meaning the sample members are allocated to treatment groups by chance alone so that the choice reduces the risk of possibly biasing factors
RANDOMIZED CONTROL TRIAL (RCT)
- lack of representativeness
- “a process at any stage of inference tending to produce results that depart systematically from the true values”
BIAS
Occurs when two factors are associated with each other and the effect of one is confused with or distorted by the effect of the other
CONFOUNDING BIAS
are factors (exposures, interventions, treatments, etc) that explain or produce confounding
Confounder
- Creates problems in statistical analysis
- Affects comparability of treatment and control groups
Problems with Sample Attrition
Treatment maybe so effective that patients believe themselves to have been cured and cease taking medications; successes disappear from treatment, leaving treatment appearing less effective than what it really is
Problems with Sample Attrition
- Replacement of drop-outs not advisable
- Drop-out rates should be considered in sample size estimation
Problems with Sample Attrition
indicator of therapeutic usefulness and effectiveness and should be considered when drawing conclusions from trials
Drop-out data can be used
the extent to which a measurement or study reaches the correct conclusion.
VALIDITY
The degree to which a test is capable of measuring what it is intended to measure
VALIDITY
The degree to which the result of an observation are correct for the particular group studied
INTERNAL VALIDITY
determined by how well the design, data collection, and analyses are carried out and are threatened by all the biases, and random variation
INTERNAL VALIDITY
Extent to which the study’s results can be applied to those beyond the study sample
EXTERNAL VALIDITY (Generalizability)
Assuming that the results of the study are true, do they apply to my patients as well?
EXTERNAL VALIDITY (Generalizability)
expresses the validity of assuming that patients in a study are comparable with other patients
Generalizability
Due to differences or changes in the standardized diagnostic criteria
(i. e. diagnostic custom) used by most physicians
- example: Hypertension, Rheumatoid arthritis
THE OBSERVER
Due to differences or changes in the application of diagnostic criteria by individual clinician
example: rounding off quantitative measurements (BP), carelessness, or simple ignorance
THE OBSERVER
International Classification of Diseases, 8th revision – reported a 15% increase deaths due to IHD ICD 9th revision reported reduced number of death
THE SYSTEM used for codifying and classifying observations of the phenomena of interest