MDE Flashcards

1
Q

vasopresores

hormonas, no medicamentos

A

noradrenalina
adrenalina
dopamina
fenilefrina
vasopresina

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2
Q

inotropicos

A

dopamina
dobutamina
milrinona
levosimendan

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3
Q

tipos de farmacos inotropicos

A

glucosidos cardiacos
aminos adrenergicos
inhibidores de la fosfodiesterasa
moduladores de sensibilidad al calcio

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4
Q

aminos adrenergicos

A

dopamina
dobutamina

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5
Q

inhibidores de la fosfodiesterasa

A

milrinona

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6
Q

moduladores de la sensibilidad al calcio

A

levosimendan

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7
Q

mecanismo de accion de dopamina/ dobutamina

A

agonistas beta 1
proteina Gs –> aumento cAMP –> apertura canales calcio

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7
Q

mecanismo de accion milrinona

A

inhibicion de PDE3 –> no hay degradacion de cAMP –> acumulacion de cAMP –> apertura de canales de calcio

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8
Q

mecanismo de accion de levosimendan

A

union con troponina C –> prolongacion de cambios conformacionales –> aumentan el calcio

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8
Q

tipos de inmunosupresores

A

inh. de calcineurina
corticosteroides
inh. señales de proliferacion (contra mTOR y JAK3)
inh. sintesis nucleotidos
inh. migracion linfocitaria
inh. activacion linfocitaria

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9
Q

inh. de calcineurina

A

ciclosporina A
tacrolimus

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10
Q

corticosteroides

A

metilprednisolona
prednisona

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10
Q

inh. de señales de proliferacion linfocitaria contra mTOR

A

sirolimus
everolimus

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11
Q

inh. de señales de proliferacion linfocitaria contra JAK3

A

tofacitinib

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11
Q

inh. de sintesis nucleotidos

A

azatioprina
micofenolato
leflunomida
metotrexato

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12
Q

inh. migracion linfacitaria

A

fingolimod

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13
Q

inh. de acitvacion linfocitaria contra proteinas de fusion

A

belatacept
abatacept

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14
Q

inh. de acitvacion linfocitaria con anticuerpes monoclonales

A

alemtuzumab
basiliximab
daclizumab

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15
Q

tipos de inhibidores de sintesis de pared celular

A

beta-lactamicos
glucopeptidos
lipoglucopeptidos
polipeptidos
inh. de beta-lactamasas

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16
Q

tipos de alteradores de estructura de pared celular

A

polimixinas
lipopeptidos

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17
Q

tipos de tuberculostaticos

A

activos sobre mem. celular
inh. sintesis mem. celular
inh. sintesis acidos nucleicos

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18
Q

tipos de inh. sintesis proteica

A

aminoglucosidos
tetraciclinas
gliciciclinas
oxazolidinonas
macrolidos
lincosamida

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19
Q

tipos de antimetabolitas

A

sulfamidas
trimetoprim
trimetoprim-sulfametoxazol

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20
Q

tipos de beta-lactamicos

A

pinicilinas
cefalosporinas
carbapenems

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21
Q

glucopeptidos

A

vancimicina
teicoplanina

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22
Q

lipoglucopeptidos

A

dalbavancina
telvancina

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23
Q

polipeptidos

A

bacitracina

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24
Q

polimixinas

A

polimicinas B + E
colistina

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25
Q

penicilinas

A

benilpenicilina
penoximetilpenicilina

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26
Q

penicilinas de amplio espectro

A

ampicilina
amoxicilina

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27
Q

penicilinas resistentes a penicilinasas

A

metilcilina
cloxacilina

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28
Q

combinaciones beta-lactamicos con inh. de beta-lactamasas

A

amoxilina + acido clavulonico
ampicilina + sulbactam
ceftazidima + avibactam

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29
Q

cefalosporinas 1º generacion

A

cefalotina
cefazolina

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30
Q

cefalosporinas 2º gen

A

cefuroxima

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31
Q

cefalosporina 3º gen

A

cefisima
cefotaxima
ceftriaxona
ceftazidima

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32
Q

cefalosporinas 4º gen

A

cefepima

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33
Q

cefalosporinas 5º gen

A

ceftarolina

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34
Q

carbapenems

A

imipenem
meropenem
doripenem
ertapenem

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35
Q

tuberculostaticos activos sobre mem. celular

A

isoniazida
etionamida
etambutol
cicloserina

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36
Q

tuberculostaticos inh. sintesis mem. celular

A

pirazinamida (PZA)
dofazimina

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37
Q

tipos tuberculostaticos inh. de acidos nucleicos

A

quinolonas
fluoroquinolonas
rifamicinas
metronidazol

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38
Q

quinolonas

A

levofloxacina

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39
Q

rifamicinas

A

rifampicina
rifabutina

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39
Q

fluoroquinolonas

A

levofloxacino
delafloxacino
ciprofloxacina

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40
Q

aminoglucosidos

A

gentamicina
tobramicina
son irreversibles

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41
Q

tetraciclinas

A

doxiciclina
minociclina

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42
Q

glicilciclinas

A

tigecidinas

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43
Q

oxazolidinonas

A

linezolid
tedizolid

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44
Q

macrolidos

A

claritromicina
azitromicina

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45
Q

lincosamida

A

clindamicina

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46
Q

sulfamidas

A

sulfametoxazol

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47
Q

trimetoprim-sulfametoxazol

A

cotrimoxazol

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48
Q

antirretrovirales contra herpes

A

cidofovir
aciclovir
valacicliovir
famiciclovir

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49
Q

antirretrovirales contra citomegalovirus

A

cidofovir
faniclovir
valganciclovir

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50
Q

antirretrovirales contra hep B

A

adenofovir

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51
Q

antirretrovirales contra HPV

A

cidofovir

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52
Q

antirretrovirales contra adenovirus

A

cidofovir

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53
Q

antirretrovirales contra covid

A

remdesivir
ancuerpos monoclonales

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54
Q

antitivral inh. de correceptores

A

maraviroc

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55
Q

antitivral inh. de integrasa/ integracion de DNA en genoma

A

raltegravir

56
Q

antitivral inh. de proteasas

A

azidotiminidina

57
Q

antitivral inh. de fusion

A

amantidina
rimantidina

58
Q

antitivral inh. de ensamblaje

A

zanamivir
oseltamivir

59
Q

antitivral inh. de hipermutaciones

A

ribavirina

60
Q

antitivral inh. de sintesis proteica

A

saquinavir
indinavir
boceprevir
telaprevir

61
Q

antitivral inh. de replicacion genomico

A

aciclovir
gancivlovir

62
Q

antirretrovirales contra HIV

A

saquinavir
indinavir

63
Q

antirretrovirales contra hep C

A

boceprevir
telaprevir

64
Q

antifungicos inh. sintesis pared celular

A

esquinocandinas

65
Q

antifungicos inh. de sintesis membrana celular

A

azoles
polienos
terbinatina

66
Q

antifungicos inh. sintesis DNA

A

flucitosina
(muy toxico)

67
Q

esquinocandinas

A

caspofungina
anidulafungina

68
Q

azoles

A

fluconazol
isavuconazol
itraconazol
voriconazol

69
Q

polienos

A

anfotericina B (AmB)
nistatina

70
Q

tipos antifungicos contra levaduras

A

azoles (itraconazol, isavuconazol)
polienos
esquinocandinas

71
Q

tipos antifungicos contra filamentos

A

azoles:
itraconazol, isavuconazol

72
Q

tipos antifungicos contra dimorficos

A

azoles

73
Q

tto staphyloccocus aureus

A

amoxicilina + ac. clavulanico
metilcilina
vancomicina

74
Q

tto staphylococcus saprophyticus

A

nitrofurantoina
cotrimoxazol

75
Q

tto streptococcus pyogenes

A

penicilina
ceftriaxone
azitromicina

76
Q

tto streptococcus agalctiae

A

penicilina G
ampicilina
cefazolina/ vancomicina (alergia)

77
Q

tto streptococcus penumoniae

A

penicilina G/ V
cefalosporinas
fluoroquinolonas/ amoxicilina + ac. clavulonico (alergias)

78
Q

tto staphylococcus epidermidis

A

vancomicina
linezolid
daptomicina
dalbavancina

79
Q

vacunacion streptococcus pneumoniae

A

polisacaridica 23 antigenos
conjugada 13 antigenos

80
Q

tto streptococcus viridans

A

penicilina
ampicilina
cefalosporinas
vancomicina
linezolid

81
Q

tto enterococcus faecalis

A

penicilina/ ampicilina + gentamicina
vancomicina
linezolid/ daptomicina (alergia)

82
Q

tto actinomyces isarelii

A

penicilina
doxiciclina/ clindamicina (alergia)

82
Q

tto nocardia

A

cotrimoxazol
imipenem
linezolid

83
Q

tto corynebacterium diptheriae

A

penicilina + antitoxina
eritromicina (alergia)

84
Q

vacuna corynebacterium diptheriae

A

toxoide inactivado
niños 6 meses - 6 años

85
Q

tto listeria monocytogenes

A

ampicilina + gentamicina IV
meropenem (embarazo/ alergia)

86
Q

tto bacillus cereus

A

vancomicina
imipenem
gentamicina

86
Q

tto bacillus anthracis

A

ciprofloxacina + clindamicina/ linezolid IV
raxicumab/ oblitoxaximab + antitoxina (casos severos)

87
Q

tto escherichia coli

A

s. hemolitico uremico: corticosteroide, plasmaferesis
UTI: cotrimoxazol, nitrofurantoina, fluoroquinolonas

87
Q

tto enterobacter

A

carbapenems
fluoroquinolonas
aminoglucosidos
polimixinas

88
Q

tto klebsiella pneumoniae

A

nunca en monoterapia
beta-lactamasas
carbapenems

89
Q

tto salmonella enteritidis

A

cefalosporinas
carbapenems
fluoroquinolonas

90
Q

tto salmonella typhi

A

fluoroquinolonas
cefalosporinas

91
Q

vacuna salmonella typhi

A

inactivada intramuscular
viable oral

92
Q

tto yersinia enterocolitica

A

cefalosporinas 3º
cotrimoxazol
aminoglucosidos
fluoroquinolonas
tetraciclinas

93
Q

tto yersinia pestis

A

gentamicina
doxiciclina
fluoroquinolonas
clorandenicol
10-14 dias

94
Q

tto vibrio cholerae

A

casos extremos
fluoroquinolonas
tetraciclinas
cotrimoxazol

95
Q

tto shigella

A

beta-lactamicos
macrolidos
quinolonas

96
Q

tto campylobacter jejuni

A

eritromicina
azitromicina

97
Q

tto helicobacter pylori

A

inh. bombas H+ + amoxicilina + claritromicina + metronidazol

98
Q

tto pseudomonas aeruginosa

A

beta-lactamico + aminoglucosido
carbapenems + fluoroquinolonas + aminoglucosido

99
Q

tto neisseria meningitidis

A

ceftriaxona
profilaxis: ceftriaxona, rifampicina, ciprofloxacina

100
Q

vacuna neisseria meningitidis

A

conjugada = niños
recombinante = adultos

101
Q

tto neisseria gonorrhoae

A

ceftriaxona
azitromicina/ doxiciclina en coinfeccion chlamydia trachomonis

102
Q

tto haemophilus influenzae

A

cetriaxona/ cefotaxima (meningitis)
amoxicilina + ac. clavulonico, cefuroxima, macrolidos, fluoroquinolonas (inf. mucosa)
profilaxis niños: rifampicina

103
Q

vacuna haemophilus influenzae

A

polisacaridica capsular tipo b + toxoide tetanico
niños 2-18 meses

104
Q

tto haemophilus ducreyi

A

azitromicina/ ceftriaxona (1 dosis)
ciprofloxacino/ eritromicina (varias dosis)

105
Q

tto moraxella catarrhalis

A

amoxicilina + ac. clavulanico
azitromicina
claritromicina
cotrimoxazol

106
Q

tto gardenella vaginalis

A

metronidazol
7 dias

107
Q

tto legionella pneumophila

A

azitromicina
levofloxacina

108
Q

tto bordetella pertussis

A

macrolidos
en fase catarral o principios de fase paroxistica

109
Q

vacuna bordetella pertussis

A

acelular
muy eficaz

110
Q

tto pasteurella multocida

A

penicilina
tetracilina
cefalosporina
fluoroquinolona

111
Q

tto bartonella henselae

A

ciprofloxacina
gentamicina
doxiciclina

112
Q

tto francisella tularensis

A

estreptomicina
gentamicina
tetraciclina
fluoroquinolona

113
Q

tto brucella

A

gentamicina/ estreptomicina
doxiciclina + rifampicina (niños, embarazadas)
45 dias tto

114
Q

tto mycobacterium tuberculosis

A

latente = isoniazida 9 meses
activa = isoniazida + etambutol/ estreptomicina + aislamiento

115
Q

tto mycobacterium leprae

A

lepre lepromatosa = dapsona + rifampicina + clofaziminina 12 meses
lepre tuberculosa = dapsona + rifampicina 6 meses

116
Q

tto influenza

A

ozeltamivir/ zanamivir, amanitidina

117
Q

vacuna influenza

A

trivalente inactivada intramuscular
trivalente atenuada intranasal

118
Q

tto virus humano parainfluenza (HPIV)

A

sintomatologia
obstrucciones aereas = corticosteroides/ epinefrina nebulizada

119
Q

virus respiratorio sinciticial (VRS)

A

palizumab en niños con riesgo

120
Q

tto rhinovirus

A

sintomatologia

121
Q

tto adenovirus

A

casoso severos = cidofovir, inmunoterapia

122
Q

vacuna adenovirus

A

viva para gente con alto riesgo

123
Q

tto herpes simple (VHS)

A

aciclovir, valaclovir, famiciclovir

124
Q

tto varicela/ varicela zoster

A

aciclovir, valaciclovir, famiciclovir
inmunoglobolinua especifica humana

125
Q

vacuna varicela/ varicela foster

A

atenuada de cepa OKA

126
Q

tto epstein barr (VEB)

A

no hay

127
Q

tto citomegalovirus (CMV)

A

ganciclovir/ valganciclovir
cidofovir/ foscarnet
analizar ressitencias secuenciando gen UL97 (fosfotransferasa) o UL54 (DNA pol)

128
Q

tto herpes virus 6

A

aciclovir, ganciclovir

129
Q

tto herpes virus 8

A

casos severos (VIH+) = quimioterapia + antirretrovirales

130
Q

tto norovirus

A

sintomatologia

131
Q

tto rotavirus

A

sintomatologia

132
Q

vacuna rotavirus

A

atuenuada oral

133
Q

tto poliovirus

A

sintomatologia

134
Q

vacuna poliovirus

A

Salk = subcutanea trivalente inmunidad IgG (no IgA)
Sabin = oral atenuada inmunidad celular y humoral (IgG y IgA)

135
Q

tto entervirus no-polio

A

sintomatologia

136
Q

vacuna hepatitis A

A

inactivado

137
Q

tto hepatitis E

A

ribavirina en inmuno deprimidos

138
Q

vacuna hepatitis D

A

vacuna HBV (de hep B)

139
Q

tto hepatitis C

A

daclatasvir + sofosbuvir

140
Q

tto hepatitis B

A

aguda grave = lamivudina
cronica = INF alfa + (lamivudina/ entecavir/ telvidubina o adenofovir/ tenofovir)

141
Q

vacuna hepatitis B

A

HBs recombinante 3 dosis
globulina hiperinune de suero de paciente para ya infectados (mejorar sintomatologia)