May 16 Flashcards

1
Q

Ischemic infarct CT appearance

A

Hypodense, poorly delinieated

Edema, loss of grey/white matter distinction

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2
Q

Infarct course

A

During first 48 hours, red neurons.
Neutrophils move in, then microglia (macrophage).
Microglia stain the strongest as fat cells. (Break down stuff, cause of liquefactive necrosis)

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3
Q

Acute decompensated heart failure in CXR

A

Cardiomegaly
Secondary pulmonary edema (kerly b lines).
Perihilar alveolar edema (batwing)

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4
Q

Path of CSF flow

A

Choroid plexus secretes, lateral ventricle->interventricular foramen of monro -> third ventricle -> cerebral aqueduct -> fourth ventricle -> foramina of Luschka and Magendie -> subarachnoid space.
Absorbed y arachnoid granulations into venous sinus.

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5
Q

DSM5 for tourette

A

Multiple motor and one+ vocal tic (not necessarily concurrent)
>1 year.
Before 8
Treat with: antipsychitics, alpha-receptor antagonist, therapy

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6
Q

Filtration Fraction

A

FF = GFR/ RPF
GFR: creatnine.
RPF: PAH.
Clearance (urine X flow / serum).

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7
Q

Consequence of giardiasis

A
Lactose intolerance (lactase deficiency)
Lactose -> Galactose
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8
Q

Projection

A

Misattributing one’s own feelings to another who doesnt have them.
I lost the game. They must be ashamed of me (when really I’m ashamed).

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9
Q

TNF-alpha inhibitors

A

Adalimumab, infliximab, etanercept.

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10
Q

G6PD

A

X linked
Rate limiting in Pentose Phosphate (Glucose -6- phosphate to 6-phpsphogloconate (creating NADPH).
Oxidative damage causes hemolysis. (TMP/SMX for UTI can cause)

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11
Q

Acidos/alkalosis compensaton

A

Met Acid: pH down, pCO2 down (HyperVent), HCO3 down.
Resp Acid: pH down, pCo2 Up, HCO3 up.
Met Alk: pH up, pCO2 up, HCO3 up.
Resp alk: pH up, pCO2 down, HCO3 down.

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12
Q

Ankylosing spondylitis

A

Low back pain, improves with exercise but not rest (pain at night).
Hip, butt.
Limited chest expansion, chest mobility.
Systemic issues (fever, chills).
B27

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13
Q

Foot drop

A

Mostly common peroneal nerve

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14
Q

How is isoniazid metablized?

A

Liver. Acetylation (phase II)

Also: procainamide, hydralazine, TNF-alpha inhibitors.

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15
Q

Epinephrine effects

A

Alpha 1= vascular smooth muscle. VasoC.
Beta 1= skeletal smooth muscle. VasoD. increase heart rate.
If high dose, alpha 1 predominate, increased BP. If low, beta2 = decreased blood pressure.

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16
Q

Which HIV gene is related to rsistance to drugs?

A

Pol = to reverse transcriptase inhibitor and protease inhibtor
ENV: to escape antibodies (capsule).

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17
Q

Drugs used for PBH AND HTN

A

Doxazosin, prazosin, terazosin

Alpha 1 lockers. Useful for vasoD too.

18
Q

Corticosteroids increase what immune cell?

A

Neutrophil. Bc demargination.

Previously attached to vessel wall, so they release.

19
Q

Enteric bacteria produce what?

A

Folate

Vitamin K

20
Q

Absence seizures

A

Mostly kids.
No postictal period. No recollection.
Ethosuximide or sodium valproate.
3Hz spike in EEG.

21
Q

Amniotic fluid embolism

A
Cardiognic shock
Respiratory failure, hyoxemic
DIC
Seizures, coma
Histology shows: fetal squamous cell and mucin in pulmonary arteries of mom.
22
Q

Kallmann syndrome

A

Failure of GnRH secreting neurons to migrate. KAL1 mutation or FGFR1 mutation (codes for migration).
Hypogonadism, anosmia.
Delayed puberty.

23
Q

Delayed puberty

A

14 in boys

12 in girls

24
Q

Southwestern blot

A

Used to identify proteins that bind to DNA.

25
Q

Choronic kindey disease

A
GFR down.
VitD (1,25,dihydroxyvitaminD) decrease (intestinal Ca+ down)
Phosphate retention (low GFR)
Low serum calcium -> high PTH trying to correct
26
Q

systemic sclerosis (limited)

A
Crest
Calcium nodules. 
Raynauds phenominon. (Can lead to ulcer)
Esophageal dysmotility
Sclerodactyly
Telangiectasia
27
Q

Rickets

A
VitD deficiency
Excess of unmineralized osteoid matriz (bc no calcium to do it)
Frontal bossing, craiotabes (soft skull) [prewalk]
Genu varum (bowing of femur) [post walk]
28
Q

Marker for fetal lung maturity

A

Phospholipids

Specifically (lectin to sphingomyelin ration (L/S), above 2

29
Q

Transport of glucose into the cell

A

Mostly by facillitated diffusion with help of GLUT

Steroselective for D-glucose

30
Q

How to reverse Methotrexate toxicity?

A
Folinic acid (leucovorin). 
THF without the need for DHF reductase (inhibited by MTX)
31
Q

Super antigen affects what cells?

A
Macrophages (MHCII)
T lymphocytes (TCR)
32
Q

Spice nucleotide

A

GU XXXXX…..XXXX AG

33
Q

CHF affects lung

A

Causes decrease in lung compliance

Fluid causes swelling of tissue

34
Q

Obstructed braciocephalic vein

A

Apical lung tumor, or thrombotic occlusion (central catheter)
Ipsilateral face swelling, subcutanous vein engorgement, and arm swelling.

35
Q

Brachiocephalic vein obstrcution vs superior vena cava syndrome

A

BV: ipsilateral
SVC: both sides

36
Q

Superomedial injection

A

Causes Trendelenburg gait. Hip drop when ipsilateral foot raised.
Injury to controlateral superior gluteal. Weaked gluteus minimus can’t contract on side of injury

37
Q

When to add mesna and for what?

A

Cyclophosphamide or ifosfamide (breast cancer)

To avoid hemorrhagic cystitis.

38
Q

RSV

A

Bronchiolitis (lower respiratory tract). Before age of 2.

Rhinorrea and congestion followed by wheezing and crackles.

39
Q

Adenomyosis

A

Endometrial glandular tissue within myometrial
Heavy menstrual bleeding
Painful
Uniformly enlarged uterus.

40
Q

Displacement

A

Emotions are transferred from person/object causing negative emotions to more neutral person/object.
“My wife cheated on me, so I yelled at my kids for doing little things”

41
Q

Spironolactone MoA

A

Aldosterone receptor antagonist
Potassim diarrhetic @ collecting duct.
Aldosterone puts in transporter (Na out/ K, H in).