Mar 5 - Topical Tx's and Inflamm Skin Disease Flashcards
What is a corneocyte?
A skill cell from the top layer of the epidermis (stratum corneum)
Three ways topical drugs can be absorbed:
Passive Diffusion, Channels/Pores, Appendageal Structures
Topical absorption is directly proportional to _____?
The concentration of the active ingredient
Topical absorption is inversely proportional to _____?
Molecular size
What is the “vehicle” for topical medications?
The vehicle is what the active ingredient is suspended in
Cremes are a mixture of:
oil in water
Ointment is a mixture of:
water in oil
Gels are a mixture of:
semi-solid emulsions in an alcohol base
Which is the most potent delivery system: ointment, gel, lotion?
Ointment
Acne keloidalis
hypertrophic scarring over time due to chronic irritant exposure
1 FTU = _____g = ______ (surface area of the body)
1 FTU = 0.5 g = covering the front and back of one hand
Which is most potent: Hydrocortisone, Clobeasol Propionate, or Triamcinolone Acetonide?
Clobetasol Propionate (class 1)
What is our all-purpose topical steroid?
Triamcinolone Acetonide
What topical steroid should you use on an infant with a skin infection on the face?
Hydrocortisone
Some adverse effects of chronic topical steroid use?
Skin atrophy
In kids: adrenal suppression, Cushing’s Disease, growth retardation
Atopic dermatitis is often caused by a mutation in which gene?
The filaggrin gene
How to Dx Atopic Dermatitis?
Itchy skin + (onset before 2 y/o, dry skin, skin creases, family history of asthma/hay fever, scaley red cheeks with the cold)
xerosis =
dry skin
Is atopic dermatitis inflammatory or non-inflammatory?
Inflammatory and recurrent
Irritant Contact Dermatitis
Not immune-mediated; chronic exposure to irritant chemicals (ie soap, heat)
Itertrigo
Rashes in skin folds due to friction/trapped sweat. Can easily become secondarily infected (candidae)
Allergic Contact Dermatitis (ACD)
Delayed hypersensitivity with contact with the allergen. Blisters and epidermal changes 24-48 hours after exposure
Which cells recognize the MHC class II on allergy antigens?
Langerhans cells
Cellulitis vs Contact Dermatitis
Cellulitis = Dermis! Pain and warmth
Contact Dermatitis = Epidermis! Itchiness with red swelling
