Mar 5 - Topical Tx's and Inflamm Skin Disease

Question 1

What is a corneocyte?

Answer 1

A skill cell from the top layer of the epidermis (stratum corneum)

Question 2

Three ways topical drugs can be absorbed:

Answer 2

Passive Diffusion, Channels/Pores, Appendageal Structures

Question 3

Topical absorption is directly proportional to _____?

Answer 3

The concentration of the active ingredient

Question 4

Topical absorption is inversely proportional to _____?

Answer 4

Molecular size

Question 5

What is the “vehicle” for topical medications?

Answer 5

The vehicle is what the active ingredient is suspended in

Question 6

Cremes are a mixture of:

Answer 6

oil in water

Question 7

Ointment is a mixture of:

Answer 7

water in oil

Question 8

Gels are a mixture of:

Answer 8

semi-solid emulsions in an alcohol base

Question 9

Which is the most potent delivery system: ointment, gel, lotion?

Answer 9

Ointment

Question 10

Acne keloidalis

Answer 10

hypertrophic scarring over time due to chronic irritant exposure

Question 11

1 FTU = _____g = ______ (surface area of the body)

Answer 11

1 FTU = 0.5 g = covering the front and back of one hand

Question 12

Which is most potent: Hydrocortisone, Clobeasol Propionate, or Triamcinolone Acetonide?

Answer 12

Clobetasol Propionate (class 1)

Question 13

What is our all-purpose topical steroid?

Answer 13

Triamcinolone Acetonide

Question 14

What topical steroid should you use on an infant with a skin infection on the face?

Answer 14

Hydrocortisone

Question 15

Some adverse effects of chronic topical steroid use?

Answer 15

Skin atrophy

In kids: adrenal suppression, Cushing’s Disease, growth retardation

Question 16

Atopic dermatitis is often caused by a mutation in which gene?

Answer 16

The filaggrin gene

Question 17

How to Dx Atopic Dermatitis?

Answer 17

Itchy skin + (onset before 2 y/o, dry skin, skin creases, family history of asthma/hay fever, scaley red cheeks with the cold)

Question 18

xerosis =

Answer 18

dry skin

Question 19

Is atopic dermatitis inflammatory or non-inflammatory?

Answer 19

Inflammatory and recurrent

Question 20

Irritant Contact Dermatitis

Answer 20

Not immune-mediated; chronic exposure to irritant chemicals (ie soap, heat)

Question 21

Itertrigo

Answer 21

Rashes in skin folds due to friction/trapped sweat. Can easily become secondarily infected (candidae)

Question 22

Allergic Contact Dermatitis (ACD)

Answer 22

Delayed hypersensitivity with contact with the allergen. Blisters and epidermal changes 24-48 hours after exposure

Question 23

Which cells recognize the MHC class II on allergy antigens?

Answer 23

Langerhans cells

Question 24

Cellulitis vs Contact Dermatitis

Answer 24

Cellulitis = Dermis! Pain and warmth

Contact Dermatitis = Epidermis! Itchiness with red swelling

Question 25

Neomycin (from Neosporin) will cross react / cross sensitize with ______

Answer 25

Vassotracen

Question 26

Statis Dermatitis presentation

Answer 26

Itchy, swollen, brown/red skin caused by inadequate venous return from the lower limbs. Can lead to ulcers and open lesions.

Question 27

Lipordermatosclerosis

Answer 27

Scarring due to dermatitis that can lead to thinning of the limb

Question 28

Nummular Dermatitis

Answer 28

Due to a decrease in circulating NMF causing coin-like, red, scaley patches. Prevalent in older Pt’s

Question 29

Suborrheic Dermatitis

Answer 29

Dandruff, in infants: cradle cap. Flaky yellow discharge from Malassezia furfur yeast consuming natural skin oils

Question 30

How do you treat Suborrheic Dermatitis?

Answer 30

Ketoconazole and anti-fungal shampoos

Question 31

Psoriasis

Answer 31

Thick, silvery, scaled rash on the trunk and extensor surfaces. Caused by an immune predisposition and an environmental trigger

Question 32

Guttate Psoriais

Answer 32

Psoriasis associated with strep pyogenes - appears like psoriasis drops all over

Question 33

What happens to your nails with psoriasis?

Answer 33

Nail pitting / separation of the nail from the nail bed

Question 34

Psoriatic Arthritis

Answer 34

Arthritis secondary to psoriasis - can lead to nail changes, painful joints/bleeds, dactylitis