Manganese

Question 1

sources of Mn

Answer 1

grain, legume, nuts, seeds, fruit, veggie

Question 2

absorption of Mn

Answer 2

throughout the SI

Question 3

absorption of Mn is enhanced by?

Answer 3

histidine

citrate

Question 4

absorption of Mn is inhibited by?

Answer 4

fiber, phytate, oxalate, iron, copper

Question 5

Mn is transported _____ or bound as ____ to a protein

Answer 5

Mn is transported free or bound as Mn2+ to a protein

Question 6

Mn2+ can be oxidized to Mn3+ and bound to _____

Answer 6

transferrin

Question 7

Mn is rapidly cleared from the blood and accumulates in the ______ of tissue cells

Answer 7

mitochondria

Question 8

highest concentrations of Mn

Answer 8

bone
liver
pancreas
kidneys

Question 9

Functions of Mn

Answer 9

manganese dependent enzymes
antioxidant
production of bone and cartilage (apatite matrix)
essential for normal brain function (neurotransmission)

Question 10

Mn is excreted

Answer 10

bile

Question 11

Signs and Sx of deficiency

Answer 11

n/v
neuro disorders
skeletal defects
increased serum Ca, P, and alkaline phosphatase
dermatitis, decreased nail/hair growth
CHANGES IN BEARD AND HAIR COLOUR

Question 12

available forms of Mn

Answer 12

aspartate
gluconate
citrate
a.a chelate

Question 13

Toxicity of Mn is seen in:

Answer 13

liver failure, chelosis

miners who inhale Mn dust

Question 14

miners who inhale Mn dust develop what type of sx

Answer 14

parkinsons like

Question 15

___ and Mn inhibit each others absorption

Answer 15

iron

Question 16

____ supplementation decreases absorb of Mn

Answer 16

Ca