Management of type 1 hypersensitivity reactions

Question 1

What are the clinical features of a type 1 hypersensivity reaction

Answer 1

• Hive - urticaria
• Asthma
• Angioneurotic oedema - non pitting
• Allergic rhinitis
• Allergic conjuntivitis
• Diarrhoea
• Vommiting
• Anaphylaxis

Question 2

What are the treatment options for type 1 hypersensivity

Answer 2

1. Targeted avoidance of allergen
2. Block mast-cell activation

• ​Mast-cell stabalisers - sodium chromoglycate
• Topical spray prophylactically - allergic rhinitis, excersie astham

3. Prevent mast cell activation

• H1-receptor antagonist - prophylaxis and symptom
• Leukotrien antagonist - Montelukast

4. Corticosteriods

5. immune therapy - but anaphylactic risk