Mammary Gland and Lactation Flashcards

1
Q

The four stages of lactation

A

Mammogenesis
Lactogenesis
Galactopoiesis
Involution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mammogenesis

A

Development of mammary gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lactogenesis

A

Initial production of milk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Galactopoiesis

A

Secretion and continued production of milk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Involution

A

Atrophy of secretory cells caused by no more suckling, decreased prolactin, and decreased GnRH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mammary gland anatomy from large to small

A

Lobe –> Lobule –> Alveolus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What hormone stimulates alveolar growth?

A

Progesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What hormone stimulates duct growth?

A

Estrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hormones involved in mammary gland development

A

Progesterone
estrogen
growth hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hormones involved in MG development during pregnancy

A

Prolactin
Adrenal corticosteroids
Placental lactogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What triggers lactogenesis?

A

Increase in prolactin and decrease in progesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Species with inguinal mammary glands

A

Ruminants, mare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Species with thoracoabdominal mammary glands

A

Dog, cat, pig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Species with thoracic mammary glands

A

Primates, elephants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mammary gland function

A

Product colostrum

Nutrition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Colostrum

A

“first milk”

provides passive transfer of immunoglobulins (mostly IgG)

17
Q

Relationship between placentation type and passive transfer

A

Less invasive placentation = more reliance on colostrum for passive transfer of immunoglobulins

Epitheliochorial > endotheliochorial > hemochorial

18
Q

Factors affecting colostrum quality

A
Age
Number of lactations
Vaccination status
Health
Volume of colostrum
19
Q

Reasons passive transfer fails

A

Inadequate supply from dam
Failure to suckle
Failure to absorb into bloodstream

20
Q

Hormones that stimulate galactopoiesis

A

Prolactin and growth hormone

21
Q

Hormone that stimulates milk letdown

A

Oxytocin (release caused by suckling)

22
Q

How can milk letdown be blocked?

A

Adrenaline from nerve endings overcomes let down hormone action

23
Q

Galactopoiesis regulation

A

More milk removal = more milk production

Less milk removal –> pressure atrophy = less milk production

24
Q

Lactogenesis exocytosis

A
  1. Casein and lactose secreted
25
Q

Lactogenesis lipid

A
  1. Fat globule released
26
Q

Lactogenesis apical transport

A
  1. Water and electrolytes
27
Q

Lactogenesis transocytosis

A
  1. secretory IgA, hormones, growth factors (IGF-1)
28
Q

Lactogenesis paracellular

A
  1. transport of IgG and leukocytes