Just the tip- sex determination Flashcards
What are the 3 stages of sexual differentiation
Chromosomal
Gonadal
Phenotypic
What is SRY
The sex determining region gene for males
What drives gonadal differentiation
Chromosomal sex
What is the precursor of the gonad
gonadal ridge
What are gamets
Primordial germ cells
Where do Primordial germ cells originate from
yolk sac
Where do primordial germ cells migrate to
gonadal ridge
What is the gonadal ridge precursor to
gonad
What gene differentiates the testies
SRY gene
What causes ovarian differentiation
Two copies of key genes
In males what do sex chords give rise to
seminiferous tubules
What do sertoli cells produce
Anti-Mullerian Hormone
What do primordial germ cells give rise to in males
spermatozoa
What do Leyding cells produce
Testosterone
What do primordial germ cells give rise to in females
oocytes
What are the two duct systems present in the early embryo regardless of chromosomal sex
Mesonephric duct (Wolffian) Paramesonephric (Mullerian)
What determines the development of the tubular tract
Presence or absence of testicular hormones
What is testosterone essential for
Development of male duct system (mesonephric)
What is Ant-Mullerian hormone cause
regression of female duct system (paramesonephric)
What do the mesonephric ducts become
Epidiymides, deferent ducts, urethra
What do the paramesonephric ducts become
oviducts, uterus, cervix, cranial vagina
What is the main determinate of phenotypic sex
dihydrotestosterone (DHT)
What do genital tubercles become in the presence/absence of DHT
PENIS/clitoris
What do genital swellings become in the presence/absence of DHT
Scrotum/vulva
What do genital folds do in the presence/absence of DHT
Close/No close
