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Malignant Heme Flashcards

1
Q

CLL/PLL is defined as?

A

11-55% PLL

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2
Q

Smudge cells artifacts caused by ?

A

EDTA(purple) – also satellitosis is seen in EDTA

You dont see either with Heparin (green)

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3
Q

In CLL, the most common cytogenetic abnormality is ___ but by FISH, the most common anomaly is _____

A

Trisomy 12

Fish: del 13q14

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4
Q

Whats the RAI and the Binet?

A 
Rai
0 Lymphocytosis
I. Lymphadenopathy
II. hepatosplenomegaly
III. anemia (=<11)
IV. Thrombocytopenia (<100,000)

Binet
A < 3 lymphoid areas
B >3 lymphoid areas
C Anemia and thrombocytopenia

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5
Q

CD19, CD20(dim), CD22, CD5, CD43, CD23, sIg (dim), CD79a, CD11c(dim), bcl-2

A

CLL

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6
Q

CD19, CD20(bright), CD22, FMC-7, CD5, CD43, sIg(Bright) bcl-1, CD99

A

Mantle

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7
Q

Adverse prognosis for mantle?

A

> 10 mitosis/hpf

Ki-67 >40%

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8
Q

Diffuse growth in FL is defined as?

A

follicular architecture with a lack of CD21 and or CD23

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9
Q

Prognosis of FL is adversely affected by?

A

Higher age, stage, serum LD, BM involvement, B symptoms, anemia, low performance status

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10
Q

CD19, CD20, CD22, sIg, CD11c(Bright), CD25(bright), CD103, DBA.44. annexin A1, cyclin D1(dim,nuclear)

A

Hairy cell

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11
Q

LPL with an IgM monoclonal gammopathy and marrow involvement is?

A

Waldenstrom macroglobulinemia

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12
Q

Waldenstrom is associated with?

A

HCV and cryoglobulinemia

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13
Q

t(9:14) Pax5 gene and C region of IgH is seen in?

A

LPL

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14
Q

Which bacteria is associated with a form of MALT lymphoma called the immunoproliferative small intestine disease (mediterranearn lymphoma)

A

Campy jejuni

This heavy chain disease is associated with the alpha type.

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15
Q

Franklin H chain disease (y heavy chain disease) seen in?

A

LPL

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16
Q

u heavy chain disease is seen in?

A

CLL

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17
Q

GCB-like DLBCL is associated with?

A

better prognosis

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18
Q

BM infiltration by TCRBCL is

A

paratrabecular

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19
Q

Which large B lymphoma is associated with
MAL gene alteration
Females
no rearrangement of BCL2 or BCL6
Large b cells entrapped within bands of scleorsis?

A

Primary mediastinal (thymic) large b cell lymphoma

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20
Q

HIV/HHV8 combo seen in?

A

Kaposi
PEL
Castleman

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21
Q

Which Large B cell Lymphoma

resembles vasculitis
Associated with EBV and immunodeficiency
Uncommon granulomas
large number of reactive T cells, plasma, histiocytes

A

Lymphomatoid granulomatosis

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22
Q

CD19, CD20, CD22, CD10, bcl-6, sIg, C-myc

A

Burkitt

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23
Q

In B-ALL, what are the favorable findings?

A

Low initial white count (<50,000)
2-10 years
Female
Hyperdiploidy

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24
Q

IN B-ALL with recurrent abnormalities, which are good prognosis?

A

t(12;21) TEL-AML1
Hyperdiploid >50

Both seen in 25% of children

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25
Q

IN B-ALL with recurrent abnormalities, which are associated with badprognosis?

A

t(9;22) 190k Most common and worst
t(v;11) MLL CD10-
Hypodiploid
t(1;19) E2A-PBX1

26
Q

IN B-ALL with recurrent abnormalities, which is associated with eos?

A

t(5;14) IL3-IGH - NO CHANGE IN PROGNOSIS

in AML its inv(16)

27
Q

With MM by fish, what has the shortest survival median of 24 months?

A

t(4;14), t(14;16) or 17p13 deletion

28
Q

With MM by fish, what has the longest survival median of >50 months?

A

Nothing or just t(11;14)

29
Q

Smoldering myeloma vs MGUS

A

Smoldering M protein >3g/dl or clonal plasma cells in marrow is >10%
MGUS is less

30
Q

Which T cell lymphoma is

EBV associated, older adults

coombs+ autoimmune hemolytic anemia, cold agglutinins, anti-smooth muscle antibody, rheumatoid factor, and polyclonal hypergammaglobulinemia?

A

AITCL

Angioimmunoblastic

31
Q

Which T cell lymphoma is

associated with HTLV-1
CD25 +

A

ATCL

Adult T cell leukemia/lymphoma

32
Q

Which T cell lymphoma is

neutropenia, splenomegaly, polyclonal hypergammaglobulienmia

Older males’
Rheumatoid arthritis

A

T cytotoxic LGL leukemia

33
Q

Which T cell lymphoma is

young males
B symptoms
isochrome 7q

A

Hepatosplenic TCL
gamma delta type

Alpha beta more seen in females

34
Q

Which Hodgkin has the highest associated with EBV?

A

Mixed Cellularity- CHL 75% Also assoc. with HIV

LR and LD is 50%

NS is 25%

35
Q

Sideroblasts have at least ___ siderosomes that surround ___ of the nucleus

A

Sideroblasts have at least 5 siderosomes that surround 1/3 of the nucleus

36
Q

SF3B1 mutation in MDS is called?

A

MDS with ringed sideroblasts

37
Q

Dyspoiesis must be present in ___ or more of a cell line to be called dysplastic

A

Dyspoiesis must be present in 10% or more of a cell line to be called dysplastic

38
Q

Favorable prognosis for MDS?

A

Normal

isolated loss of Y,5q-, 20q-

39
Q

Unfavorable prognosis for MDS?

A

3 more more anomalies

anomalies of chromosome 7

40
Q

JAK2 is most commonly seen in?

41
Q

Name that AML translocation/gene name and Prognosis?

Thrombocytosis
giant agranular platelets
Adults

A

AML with inv 3 or t(3;3)
RPN1/EVI1
Poor prognosis

42
Q

Name that AML translocation/gene name and Prognosis?

Basophilia
Children/adults

A

t(6;9) DEK/NUP214

poor prognosis

43
Q

Name that AML translocation/gene name and Prognosis?

Megakaryocytic
CD34 and HLA-DR negative
INfants

A

t(1;22) RBM15/MLK1

intermediate prognosis

44
Q

Name that AML translocation/gene name and Prognosis?

Abundant gray blue cytoplasm
Auer rods
large granules
CD19+
YOung adults
A

t(8;21) RUNX1/RUNX1T1

Favorable

45
Q

Name that AML translocation/gene name and Prognosis?

abnormal eos- stain with naphthyl acetate esterase
lysozyme and CD2 pos
young adults

A

inv (16) MYH11/CBFb

favorable

46
Q

Name that AML translocation/gene name and Prognosis?

Promyelocytes
CD34 and HLADR neg
Middle age
Females

A

t(15;17) PML/RARa

favorable

47
Q

In AML with myelodysplasia related changes, how much dysplasia is need?

A

> 50% in 2 cell lines

48
Q

Which AML is associated with mediastinal germ cell tumors and i12p?

A

Acute megakaryoblastic leukemia M7

49
Q

CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD34 negative, CD56 positive, TdT negative, and Epstein Barr virus (EBV) positive.

A

Aggressive natural killer (NK)-cell leukemia

50
Q

CD2 positive, CD3 positive, CD4 negative, CD5 negative, CD8 negative/positive, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative.

A

Hepatosplenic T-cell lymphoma

51
Q

CD2 negative, CD3 negative, CD4 negative, CD5 negative, CD8 negative, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative. In addition, the cells are CD138 positive, CD38 positive (bright), CD79a positive, and CD20 negative/positive.

A

Plasma cell leukemia

52
Q

CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD19 negative, CD34 negative, CD56 positive, TdT negative, and EBV positive.

A

Extranodal NK/T-cell lymphoma

53
Q

CD3 positive, CD5 positive, CD7 negative, CD4 positive, CD8 negative, and CD25 positive

A

adult T-cell leukemia/lymphoma

54
Q

hemophagocytic lymphohistiocytosis (HLH) is associated with?

A

subcutaneous panniculitislike T-cell lymphoma

Hepatosplenic T cell lymphoma

55
Q 
5 of the following is diagnostic of?
Fever
Splenomegaly
Bicytopenia
Hypertriglyceridemia or Hypofibrinogenemia
Hemophagocytosis
Hyperferritinemia
High sCD35
56
Q

CD4, CD56, CD123, TCL1

A

Blastic plasmacytoid dendritic cell neoplasm

57
Q

MYD88 mutations are seen in?

58
Q

Hairy cell is associated with what mutation?

A

BRAF V600 E

59
Q

CXCL-13 is expressed by?

60
Q

What clinical findings has adverse prognosis in MM?

A

High B2 microglobulin, high plasma cell labeling index, high stage

Pathology (16 decks)

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